There is clear room for improvement in the knowledge base and confidence level of physicians treating snakebites in Hong Kong. Key components of management, such as ASV choice, indications, dosing, and clinical endpoints for administration, were sources of confusion to the participants in this study. The results demonstrate the need for a locally developed and widely distributed snakebite management protocol.

Objective: To investigate the accuracy of using the ratio of pre-epiglottis space distance (Pre-E) and the distance between the epiglottis and the vocal folds (Pre-E/E-VF) measured by the ultrasound to predict potential difficult airway in the Chinese population. Design: A prospective clinical study. Setting: The pre-operative assessment service clinic of Tuen Mun Hospital. Patients: Patients with age of 18 years or above, who were scheduled for elective surgery requiring general anesthesia with direct laryngoscopy and tracheal intubation. Results: A total of 113 patients with direct laryngoscopic assessment during elective operations were included. Thirty-nine (34.5%) patients had potential difficult airway which was defined as documented Cormack-Lehane classification grade 2b, 3, or 4 by the anesthetists. Measurement of the distance from the epiglottis to the anterior vocal folds (Pre-E/aVF) ratio had better inter-rater reliability and accuracy comparing to the measurements of the distances from the epiglottis to the midpoint between the vocal folds and to the posterior vocal folds. The performance of using the Pre-E/aVF ratio to predict potential difficult airway was compared with other clinical tests (the Mallampati classification, the thyromental distance and the neck circumference to thyromental distance ratio). By using the Pre-E/aVF ratio of 1, the sensitivity and specificity to predict a potential difficult airway were 79.5% and 39.2%, respectively (p = 0.044). The ultrasound assessment method had a comparable predictive value as the Mallampati classification (the area under the receiver operator characteristic curves 0.648 vs 0.687). The negative likelihood ratio of the ultrasound assessment method was the lowest among all the other airway assessment methods.

Background: With the flourishing application of botulinum toxin cosmetically and therapeutically is the emergence of iatrogenic botulism, a new type of botulism in addition to the traditional ones. Objectives: We aim at a comprehensive review of the clinical characteristics of iatrogenic botulism. Methods: The available publications are retrieved and studied. Results: Botulinum toxin blocks cholinergic transmission in the neuromuscular junctions and autonomic ganglia. The blockade can spread from the site of tissue injection to adjacent or sometimes far off structures, resulting in inadvertent disabling or even lethal effects. On literature review, weakness and dysphagia are the commonest complications of iatrogenic botulism, whereas ophthalmological and oropharyngeal symptoms are more prevalent in the cosmetic group and dyspnea in the therapeutic group. Antitoxin therapy is required in about 20% of the patients. Diagnosis of iatrogenic botulism is primarily clinical and should not be confused with the neurological diagnoses possessing similar clinical manifestations. Vigilance to the drug formulation, dosage, and administration during botulinum toxin injection are part of the preventive measures in minimizing the occurrence of iatrogenic botulism. Conclusion: While overlapping with the traditional types of botulism, iatrogenic botulism carries its unique clinical characteristics.

Background Due to the ageing population in Hong Kong, the importance and need of palliative care and end-of-life (EOL) care are coming under the spotlight. The objectives of this study were to evaluate the attitudes of emergency doctors in providing palliative and EOL care in Hong Kong, and to investigate the educational needs of emergency doctors in these areas. Methods A questionnaire was used to study the attitudes of ED doctors of six different hospitals in Hong Kong. The questionnaire recorded the attitudes of the doctors towards the role of palliative and EOL care in EDs, the specific obstacles faced, their comfort level and further educational needs in providing such care. The attitudes of emergency doctors of EDs with EOL care services were compared with those of EDs without such services. Results In total, 145 emergency doctors completed the questionnaire, of which 60 respondents were from EDs with EOL care services. A significant number of participants recognized that the management of the dying process was essential in ED. Providing palliative and EOL care is also accepted as an important competence and responsibility, but the role and priority of palliative and EOL care in ED are uncertain. Lack of time and access to palliative care specialists/ teams were the major barriers. Doctors from EDs with EOL care services are more comfortable in providing such care and discuss it with patients and their relatives. Further educational needs were identified, including the management of physical complaints, communication skills, and EOL care ethics. Conclusions The study identified obstacles in promoting palliative and EOL care in the EDs Hong Kong. With the combination of elements of routine ED practice and a basic palliative medicine skill set, it would promote the development of palliative and EOL care in Emergency Medicine in the future.

In zopiclone overdose, there may be oxidative stress rendering the development of not only methemoglobinemia but also hemolysis.