Objective: To investigate the accuracy of using the ratio of pre-epiglottis space distance (Pre-E) and the distance between the epiglottis and the vocal folds (Pre-E/E-VF) measured by the ultrasound to predict potential difficult airway in the Chinese population. Design: A prospective clinical study. Setting: The pre-operative assessment service clinic of Tuen Mun Hospital. Patients: Patients with age of 18 years or above, who were scheduled for elective surgery requiring general anesthesia with direct laryngoscopy and tracheal intubation. Results: A total of 113 patients with direct laryngoscopic assessment during elective operations were included. Thirty-nine (34.5%) patients had potential difficult airway which was defined as documented Cormack-Lehane classification grade 2b, 3, or 4 by the anesthetists. Measurement of the distance from the epiglottis to the anterior vocal folds (Pre-E/aVF) ratio had better inter-rater reliability and accuracy comparing to the measurements of the distances from the epiglottis to the midpoint between the vocal folds and to the posterior vocal folds. The performance of using the Pre-E/aVF ratio to predict potential difficult airway was compared with other clinical tests (the Mallampati classification, the thyromental distance and the neck circumference to thyromental distance ratio). By using the Pre-E/aVF ratio of 1, the sensitivity and specificity to predict a potential difficult airway were 79.5% and 39.2%, respectively (p = 0.044). The ultrasound assessment method had a comparable predictive value as the Mallampati classification (the area under the receiver operator characteristic curves 0.648 vs 0.687). The negative likelihood ratio of the ultrasound assessment method was the lowest among all the other airway assessment methods.

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