A patient with herpes zoster infection affecting the second and third branches of the trigeminal nerve is reported. This case demonstrates the occurrence of a simultaneous VZV and HSV infection. Isolation of these viruses from exudates of the blisters was required to prove coexistence of the two viruses within the same blister. Relevant literature is discussed.

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Summary:The presence or absence of latent multiple infections with herpes simplex virus (HSV)-1 was investigated. DNA cleavage patterns resulting from the digestion of viral DNA by restriction enzymes were studied. The DNA cleavage patterns of asymptomatically shed viruses isolated from the saliva of subjects at different times were compared to HSV-1 isolated from patients with HSV-1 infections of the oral cavity. If a patient had HSV-1 isolated from their saliva more than two times, the asymptomatically shed viruses were used in these experiments. This criterion was met by 13 patients. All patients underwent the viral isolation procedure on separate occasions. In addition, 55 viral strains from 10 patients with HSV infections were included in the experiment. The HSV-1 lesions were caused by a reactivation of the same strain of virus. The asymptomatically shed HSV-1 viruses had identical DNA cleavage patterns in only 4 of 13 patients (31%). The viruses isolated on separate occasions from the remaining 9 patients (69%) had different DNA cleavage patterns. Several investigators have reported the existence of latent HSV multiple infections.

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Recently, a number of reports have been published on recurrent herpetic infection of the oral mucosa. In most of these cases, the infected tissue is the fixed intraoral mucosa, such as the gingiva or hard palate. Infection of movable mucosa such as the tongue, which is reported in the present paper, has not been reported in detail previously. In each of the two cases reported in the present paper, intraoral lesions were diagnosed as recurrent herpes-glossitis after isolation of the herpes simplex virus (HSV).