In recent years, computer-aided design (CAD) and computeraided manufacturing (CAM) have been widely integrated into clinical dentistry, particularly in the field of prosthetics. Unlike conventional methods, the new workflows of these CAD/CAM systems enable the fabrication of high-performance restorations [1,2]. Duret et al., in 1988, first reported the use of CAD/CAM technology for prosthesis fabrication [3]. Since the 1980s, many researchers have focused on the practical applications of these systems [4][5][6][7]. The advantages of CAD/CAM systems include increased productivity, lower costs, easier data management, and shorter treatment durations, which are beneficial for both dental surgeons and patients [8][9][10]. This technology has already been applied to fixed prosthetic appliances, such as inlays, crowns, and implant prosthetic components [11][12][13][14]. However, removable prostheses consist of several metallic (clasps, frameworks) and non-metallic (denture bases and artificial teeth) components, which render the application of the CAD/CAM system difficult. Therefore, the fabrication of removable prostheses using CAD/CAM has been delayed [15]. Currently, CAD/CAM complete dentures are fabricated by two companies (AvaDent; Global Dental Science, Scottsdale, AZ and DENTCA; Dentca Inc., Los Angeles, CA), and these dentures are available for use in edentulous patients [16][17][18][19][20][21][22][23]. Both companies allow definitive dentures to be fabricated in a few visits, and the dental materials, techniques, and fabrication processes have been established and standardized. The fabrication process for DENTCA dentures involves 3D printing technology (3DP) [24]. CAD/CAM dentures have been shown to achieve greater patient satisfaction than conventional complete dentures [19][20][21][22]. However,

AimAs our society ages, the number of people living with dementia also steadily increases. Some work has focused on masticatory behaviour as a form of daily health care that could help prevent cognitive impairment and dementia. However, it is not yet clear how masticatory behaviour influences various cognitive functions. Therefore, the purpose of this study was to examine the effect of masticatory behaviour on the decline of generalized attention, an important cognitive function.MethodsParticipants were 35 healthy, dentulous individuals without stomatognathic abnormalities (24 men, 11 women; mean age: 56.8 ± 4.8 years). All participants completed three interventions: mastication, foot‐stepping, and none (control). Pre‐ and post‐intervention measures of generalized attention were measured by using neuropsychological tests to examine general attention; the results were then compared. Simultaneously, during the generalized attention task, the functional activity of the prefrontal cortex was observed on functional near‐infrared spectroscopy.ResultsResponse time of generalized attention improved in both the masticatory and foot‐stepping interventions. There was a transient increase in oxyhaemoglobin activity in the right and left prefrontal cortices in the masticatory intervention.ConclusionsMasticatory behaviour may be involved in a partial improvement of generalized attention and may induce prefrontal cortex activity in middle‐aged and older adults.

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