CYP2C19 genotype status, as well as the grade of GERD before treatment, is one of the determinants for the success or failure of treatment of GERD with lansoprazole. The low cure rate in patients with the homozygous extensive metabolizer genotype appeared to be a result of these patients having the lowest plasma lansoprazole levels among the 3 genotype groups.

In general, standard benchmark suites are critically important for researchers to quantitatively evaluate their new ideas and algorithms. This paper proposes CHStone, a suite of benchmark programs for C-based high-level synthesis. CH-Stone consists of a dozen of large, easy-to-use programs written in C, which are selected from various application domains. This paper also analyzes the characteristics of the CHStone benchmark programs, which will be valuable for researchers to use CHStone for the evaluation of their new techniques. In addition, we present future challenges to be solved towards the practical high-level synthesis.

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The aim of this paper is to provide new stability results for sequences of metric measure spaces (X i , d i , m i ) convergent in the measured Gromov-Hausdorff sense. By adopting the so-called extrinsic approach of embedding all metric spaces into a common one (X, d), we extend the results of [GMS13] by providing Mosco convergence of Cheeger's energies and compactness theorems in the whole range of Sobolev spaces H 1,p , including the space BV , and even with a variable exponent p i ∈ [1, ∞]. In addition, building on [AST16], we provide local convergence results for gradient derivations. We use these tools to improve the spectral stability results, previously known for p > 1 and for Ricci limit spaces, getting continuity of Cheeger's constant. In the dimensional case N < ∞, we improve some rigidity and almost rigidity results in [K15a, K15b, CM15a, CM15b]. On the basis of the second-order calculus in [G15b], in the class of RCD(K, ∞) spaces we provide stability results for Hessians and W 2,2 functions and we treat the stability of the Bakry-Émery condition BE(K, N ) and of Ric ≥ KI, with K and N not necessarily constant. * Scuola Normale Superiore, 11 Dimensional stability results 38 that in the class of smooth weighted n-dimensional Riemannian manifolds (M n , d, e −V vol M n ) the RCD * (K, N ) condition, n ≤ N , is equivalent toBy combining the continuity of (1.1) with the compactness property of the class of RCD * (K, N )-spaces w.r.t. the mGH convergence, we also establish a uniform boundwhere C i are positive constants depending only on K, N < ∞, and two-sided bounds of the diameter, i.e. C i do not depend on p (Proposition 11.1). Suspension theorems. The second application is related to almost spherical suspension theorems of positive Ricci curvature. For simplicity we discuss here only the case when N ≥ 2 is an integer, but our results (as those in [St06], [K15a], [K15b], [CM15b]) cover also the case N ∈ (1, ∞). In [CM15b] Cavalletti-Mondino proved that for any RCD * (N −1, N )space, the quantity (1.1) is greater than or equal than λ 1,p (S N , d, m N ) 1/p for any p ∈ [1, ∞), where S N is the unit sphere in R N +1 , d is the standard metric of the sectional curvature 1, and m N is the N -dimensional Hausdorff measure. Moreover, equality implies that the metric measure space is isomorphic to a spherical suspension. Under our notation (1.2) as above, this observation is also true when p = ∞, which corresponds to the Bonnet-Myers theorem in our setting (see [St06] by Sturm). Note that [CM15b] also provides rigidity results as the following one: for a fixed p ∈ [1, ∞], if (λ 1,p ) 1/p is close to λ 1,p (S N , d, m N ) 1/p , then the space is Gromov-Hausdorff close to the spherical suspension of a compact metric space, a so-called almost spherical suspension theorem. The converse is known for p ∈ {2, ∞} in [K15a, K15b] by Ketterer and we extend the result to general p; in addition, combining this with the joint spectral continuity result we can remove the p-dependence in the almost spherical suspension theore...

We performed four-terminal conductivity measurements on a CoSi2 nanowire (NW) at room temperature by using PtIr-coated carbon nanotube (CNT) tips in a four-tip scanning tunneling microscope. The physical stability and high aspect ratio of the CNT tips made it possible to reduce the probe spacing down to ca. 30 nm. The probe-spacing dependence of resistance showed diffusive transport even at 30 nm and no current leakage to the Si substrate.