Background Stimulus-responsive degradable mesoporous organosilica nanoparticles (MONs) have shown great promise as drug carriers via enhancing the efficiency of drug delivery and accelerating the degradation of nanocarriers. However, it remains a great challenge to develop novel light-enabled spatial and temporal degradable MONs with both superior responsiveness for efficient anti-cancer drug delivery and safe exocytosis. Results We report a novel photo-responsive degradable hollow mesoporous organosilica nanoplatform (HMONs@GOQD). The platform is based on organosilica nanoparticles (HMONs) containing singlet oxygen (1O2)-responsive bridged organoalkoxysilanes and wrapped graphene oxide quantum dots (GOQDs). The unique hollow mesoporous structure of the HMONs guarantees an excellent drug loading and release profile. During light irradiation, 1O2 produced by the GOQDs leads to the degradation of the organosilica nanoparticles, resulting in enhanced local drug release. Conclusions We carried out in vitro and in vivo experiments using DOX as a model drug; DOX-HMONs@GOQDs exhibited high biocompatibility, accelerated degradation, and superior therapeutic efficacy during light irradiation, indicating a promising platform for clinical cancer therapy.

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The discharge of organic pollutants poses a serious threat to public health and the environment. Developing new strategies and materials to remove organic pollutants from water efficiently and completely is of great importance. Herein, a SnS2‐modified porous β‐cyclodextrin‐containing polymer (SnS2@PCDP), which was derived by nucleophilic aromatic substitution of the hydroxyl groups of both β‐CD and SnS2−OH by tetrafluoroterephthalonitrile, was prepared for the rapid, complete removal of organic pollutants from water . The porous structure and well‐defined cavities of β‐CD endow SnS2@PCDP with a facile and high adsorption capacity, and the modification with SnS2 leads to simultaneous adsorption and photodegradation processes for the rapid and complete removal of organic pollutants. In addition, SnS2@PCDP can be regenerated several times using light irradiation with no loss in performance. Overall, the efficient removal performance and excellent reusability indicate that SnS2@PCDP has potential for practical applications in the efficient treatment of organic pollutants.

To conquer the low light utilization efficiency of traditional photocatalysts-polymer composites with core-shell structure, and boost the adsorption efficiency of functional polymer in the composites. Photocatalysts surface-engineered hollow polymer spheres are successfully synthesized by a Pickering emulsion polymerization method for removal of organic pollutants from water. Batch experiments (phenol as a model molecular, BiOI 0.5 Cl 0.5 as a model photocatalysts) showed that the removal efficiency of photocatalysts surface-engineered hollow polymer spheres was higher than that of solid polymer spheres. The significant increase in removal efficiency suggests that photocatalysts surface-engineered hollow polymer spheres might serve as powerful agents in treating organics-polluted water.