Novel pH-responsive biodegradable organosilica nanoparticles as drug delivery system for cancer therapy

Yang, Shun; Fan, Jie; Lin, Shiting; Wang, Yaru; Liu, Chang

doi:10.1016/j.colsurfa.2019.124133

Cited by 21 publications

(6 citation statements)

References 39 publications

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“…62 3.1.1 pH-Responsive polymer. Due to the different pH values in the endogenous microenvironment of specific organs, tissues and pathology sites, [63][64][65][66] such as the stomach ( pH 1.5-3.5), small intestine ( pH 5.5-6.8), colon ( pH 6.4-7.0), lysosome/endosome ( pH 4.0-6.5) and tumor microenvironment ( pH 5.0-6.0). 63,[67][68][69][70][71][72][73][74][75][76][77][78][79] pH-responsive polymer delivery carriers have received increasing attention.…”

Section: Internal Stimuli-responsive Polymersmentioning

confidence: 99%

Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery

Wang

Luo

et al. 2023

Biomater. Sci.

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Section: Internal Stimuli-responsive Polymersmentioning

confidence: 99%

Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery

Wang

Luo

et al. 2023

Biomater. Sci.

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“…Hollow mesoporous silicon (Si) nanoparticles (NPs) (HMONs) have attracted much attention due to their easily designed structure, excellent biodegradability, high specific surface area, and good surface modification ability [71][72][73][74][75][76][77]. Huang et al designed HMONs with disulfide bond as nano carrier of sonosensitizer [32].…”

Section: Inorganic Nanomaterials As the Nano Carriers Of Molecular Somentioning

confidence: 99%

Recent advances in nanomaterials for sonodynamic therapy

et al. 2020

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Sonodynamic therapy (SDT), as a novel non-invasive strategy for eliminating tumor, has the advantages of deeper tissue penetration, fewer side effects, and better patient compliance, compared with photodynamic therapy (PDT). In SDT, ultrasound was used to activate sonosensitizer to produce cytotoxic reactive oxygen species (ROS), induce the collapse of vacuoles in solution, and bring about irreversible damage to cancer cells. In recent years, much effort has been devoted to developing highly efficient sonosensitizers which can efficiently generate ROS. However, the traditional organic sonosensitizers, such as porphyrins, hypericin, and curcumins, suffer from complex synthesis, poor water solubility, and low tumor targeting efficacy which limit the benefits of SDT. In contrast, inorganic sonosensitizers show good in vivo stability, controllable physicochemical properties, ease of achieving multifunctionality, and high tumor targeting, which greatly expanded their application in SDT. In this review, we systematically summarize the nanomaterials which act as the carrier of molecular sonosensitizers, and directly produce ROS under ultrasound. Moreover, the prospects of inorganic nanomaterials for SDT application are also discussed.

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“…Yang et al reported a novel pH-sensitive biodegradable hollow MONs (PBHMONs) based on the pH-sensitive cleavable bonds containing acetal moieties. 46 Here, a pH-sensitive acetal-bridged alkoxysilane was prepared, and then mixed with TEOS to form a silica source.…”

Section: Mons With Ph-triggered Degradationmentioning

confidence: 99%

Mesoporous organosilica nanoparticles: Degradation strategies and application in tumor therapy

Guan

Chen

Tian

et al. 2021

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Biodegradation is a crucial issue for silica-based mesoporous nanoparticles that is related to the biosafety in tumor therapy. Nowadays, mesoporous silica nanoparticles (MSNs) have been intensively developed to construct multifunctional nanosystems for tumor therapy due to their biocompatibility, high drug loading capacity and easy functionalization; however, their biodegradation is relatively slow and still under debate. To improve the biodegradability of silica-based mesoporous nanoparticles, a simple organic-inorganic hybridization strategy to synthesize mesoporous organosilica nanoparticles (MONs) has been successfully developed. By hybridizing the silica framework (-Si-O-Si-) with stimuli-sensitive organic moieties to form organic-inorganic network (-Si-R-Si-, R: organic moiety), when exposed to the stimuli environment, the breakdown of the organic-inorganic network could accelerate the degradation of MONs, which is great promising for MONs as a multifunctional therapeutic nanoplatform in tumor therapy. This review aims to summarize the degradation strategies for MONs to improve biodegradability in recent years, and highlight the potential applications of MONs in tumor therapy. Finally, we also discuss the challenges of MONs for tumor therapy in future clinical translation.

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Novel pH-responsive biodegradable organosilica nanoparticles as drug delivery system for cancer therapy

Cited by 21 publications

References 39 publications

Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery

Recent advances in stimuli-responsive polymeric carriers for controllable CRISPR/Cas9 gene editing system delivery

Recent advances in nanomaterials for sonodynamic therapy

Mesoporous organosilica nanoparticles: Degradation strategies and application in tumor therapy

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