An 89‐year‐old male case was hospitalized in the COVID‐19 department. His CT scan showed nodular opacities, also a variable low P O2, elevated transaminases, and a high D‐dimer concentration. The patient diagnosed with active brucellosis. Finally, he treated by combination of doxycycline and rifampicin in addition to anti‐COVID‐19 treatment.

An 89-year-old male case was hospitalized in the COVID-19 department. His computerized chest tomography scan showed nodular opacities with glass halo including peripheral distribution. The patient showed active brucellosis.Finally, his respiratory symptoms and the radiologic images had got better and the second SARS-COV-2 test and the serologic tests were negative

Background: As a zoonotic disease, human brucellosis has a wide variety of clinical manifestations, ranging from multisystem involvement to asymptomatic infection. Case Presentation: Cases with hematological abnormalities and lymphadenopathies at a referral unit to a cancer hospital from September 2021 to August 2022 were described. Follow-up and clinical symptoms led to brucellosis being diagnosed. Conclusion: Exist of lymphadenopathies associated with hematological abnormalities led to challenges in our diagnosis, especially the observation of mesenteric and retroperitoneal lymphadenopathies. A proper diagnosis and treatment for brucellosis lead to the complete resolution of lymphadenopathies. As far as we know from the literature, the association of rare symptoms with typical symptoms of brucellosis may be very confusing and delay the diagnosis. Therefore, these case reports can highlight symptoms of brucellosis that mimic a primary hematologic disorder for better and faster diagnosis.

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