Psoriasis is a common skin disease which is inflammatory, proliferative, autoimmune, and chronic with relapsing nature. It resembles with Kitibha Kustha roga ofAyurveda which is described asrelapsing disease with dry, rough, discolored skin lesions. This is a case report of psoriasis patientwho was treated conservatively with Kitibha har kashay for 3 months. The assessment of clinical improvement was made, along with the biochemical profiling and photographic analysis. Patient was also instructed to follow the do’s and don’ts of the disease for diet and lifestyle also called pathya and apthya. Parameters that were used to assess the clinical improvement were PASI score, IGA scale and grading of Ayurvedicclinical symptoms of Kitibha.The patient was given the medication prepared from the AyurvedicPharmacy, Faculty of Ayurveda, BHU in ghan form. The crude and prepared drug was standardized from Institute itself and the data of the patient was maintained by regular follow-ups. The cell line study of water extract of Khadir compound was also done to evaluate the proliferative or antiproliferative action by MTT assay. The clinical result have shown that this drug posses a very effective antipsoriatic action that has significantly reduced PASI score to nil and marked improvement in IGA scale, clinical symptoms andphotographic improvement was found. The cell line study by MTT assay has shown the antiproliferative action of Daruharidra (Berberis aristata) that was one of the constituent of Kitibha har kashay.Further study of this drug on psoriasis specific cytokines is needed to be evaluated by biochemical analysis to evaluate its role in breaking the pathology of psoriasis.