Tea in all its forms is one of the commonly consumed beverages globally, after water. Apart from just being a beverage, it also has extensive therapeutic values. The phytoconstituents of tea either in their pure form or as an extract are essential part of traditional as well as modern day medicines. Tea has shown its medicinal benefits in treating, improving and preventing many of the ailments ranging from being potential antimicrobial, antioxidant agent to being central nervous system (CNS) stimulants. This chapter focuses specifically on physiological impacts that each of its constituents have over our nervous system like role of L-theanine to enhance dopamine and serotonin levels, theobromine, and theophylline for stimulating CNS, caffeine to inhibit adenosine receptors, hence, causing increase in brain activity etc. along with many more neuroprotective properties of tea constituents.

Lemon oil (LO), also known as Citrus limonum is a highly volatile essential oil (EO) with potential therapeutic properties like anti-oxidative, anti-proliferative, anti-fungal and anti-cancerous. However, the efficacy of LO is limited due to its physiological factors such as high volatility, poor stability (particularly sensitive to sunlight) and quick degradability upon exposure. To overcome these challenges, we formulated lemon oil loaded nanoemulsion system (LO-NE) (oil-in-water), using aqueous titration method. The formulation comprised of lemon oil (LO), Tween 80 and ethanol as oil, surfactant and co-surfactant phases respectively. The existence zone of NE was established by constructing pseudo-ternary phase diagrams using different concentrations of LO, surfactant and co-surfactant (S mix ). The quantitative estimation of LO was performed using a high throughput gas chromatography, revealing the presence of various compounds like Limonene, Alpha-Pinene and Linalyl acetate followed by the estimation of total phenolics and flavonoid content. The characterization of LO-NE indicated the particle size of 60 ± 2.5 nm along with the polydispersity index of 0.125 and zeta potential of −14.9 mV. The size range of the NE particles dispersed in the colloidal system was further verified by TEM micrograph which shows size range between 46.2 -104.7 nm. All the anti-oxidant assays outcomes exhibited the higher activity of LO-NE in comparison to LO alone with lower IC 50 values. The release kinetics statistical data showed that LO-NE had a sustained release and followed the Higuchi's model How to cite this paper:

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