The booming of global environmental awareness has driven the scientific community to search for alternative sustainable approaches. This is accentuated in the 13th sustainable development goal (SDG13), climate action, where urgent efforts are salient in combating the drastic effects of climate change. Membrane separation is one of the indispensable gas purification technologies that effectively reduces the carbon footprint and is energy‐efficient for large‐scale integration. Metal–organic frameworks (MOFs) are recognized as promising fillers embedded in mixed matrix membranes (MMMs) to enhance gas separation performance. Tremendous research studies on MOFs‐based MMMs have been conducted. Herein, this review offers a critical summary of the MOFs‐based MMMs developed in the past 3 years. The basic models to estimate gas transport, preparation methods, and challenges in developing MMMs are discussed. Subsequently, the application and separation performance of a variety of MOFs‐based MMMs including those of advanced MOFs materials are summarized. To accommodate industrial needs and resolve commercialization hurdles, the latest exploration of MOF materials for a harsh operating condition is emphasized. Along with the contemplation on the outlook, future perspective, and opportunities of MMMs, it is anticipated that this review will serve as a stepping stone for the coming MMMs research on sustainable and benign environmental application.