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256 Background: Women with pancreatic cancer (PC) are known to have a longer overall survival compared with men. However, no data address the association of gender with acute medical complications in the inpatient setting. We hypothesize that women with PC have fewer inpatient medical complications than men. Methods: The Nationwide Inpatient Sample (NIS) database was queried to identify all non-surgical hospital admissions for patients with a diagnosis of pancreatic cancer for 2011. We compared inpatient complications and mortality between females and males with PC using univariate and multivariate logistic regression model. Two sample independent t-tests were used to compare all linear variables, and Chi-squared tests were used to compare categorical data. Results: Of the 16,616 PC patients analyzed, there were 8,324 females (F) and 8,292 males (M). Mean age was 69 (F) and 67 (M). Length of stay for both averaged 6 days. After adjusting for gender, age, race, inpatient chemotherapy, and comorbidities (depression, alcoholism, arthritis, coagulopathies, drug use, diabetes, hypertension, hypothyroidism, liver disease [dz], metastatic dz, obesity, perivascular dz, renal failure), multivariate analysis showed that male gender in PC patients is independently associated with increased incidence of pneumonia (p<0.001, RR 0.77), pulmonary embolism (p=0.006, RR 0.80), ileus (p=0.001, RR 0.79), and acute renal failure (p<0.001, RR 0.76). Female patients experienced higher incidence of urinary tract infection (p<0.001, RR 1.9). Although incidence of mortality for male patients with PC was higher by univariate analysis (p= 0.005), it was not significantly higher by multivariate analysis (p= 0.087). Conclusions: In this study, men admitted with PC suffer higher incidences of inpatient complications compared to women. These findings may partly explain the higher overall survival rate of women compared to men with PC. It also implicates gender as prognostic tool in the management of hospitalized PC patients.

247 Background: Patients with cancer in the head of the pancreas (HP) have a higher frequency of biliary stents, which are associated with complications requiring hospitalization. We hypothesized that hospitalized patients with cancers of the HP have a higher incidence of morbidity and mortality as compared to patients with cancer in the body (B) or tail (T). The primary aim of this study was to investigate whether anatomic location of pancreatic primary lesions is associated with complications and mortality in hospitalized patients. Methods: The Nationwide Inpatient Sample (NIS) database was queried to identify all non-surgical hospital admissions for patients with a diagnosis of pancreatic cancer (PC) for 2011. Based on ICD-9 diagnosis codes, patients were divided into three groups: H, B, and T. Patient demographics, comorbidities, medical complications, and hospitalization outcomes were compared among these 3 groups by univariate analysis. Two sample independent t-tests were used to compare all linear variables, and Chi-squared tests were used to compare categorical data. Results: In total, 4,910 patient admissions were analyzed, of which 3,590 had H, 519 B, and 801 T. No difference was observed in the mean age for all three cohorts (67-68 years). Length of hospitalization for each cohort averaged 6 days. Patient with pancreatic cancer of tail had statistically significant higher incidence of pneumonia (H 4.7%, B 6.2%, T 9.1%, p<0.001), deep venous thrombosis (H 5.5%, B 10.6%, T 13.5%, p<0.001), pulmonary embolic (H 3.3%, B 6.9%, T 9.4%, p<0.001), cerebral vascular events (H 0.7%, B 1.5%, T 2.9%, p< 0.001), ileus (H 6.0%, B 8.1%, T 10%, p<0.001), encephalopathy (H 2.0%, B 1.7%, T 3.5%, p=0.02), acute renal failure (H 13%, B 9.1%, T 15%, p= 0.005), and in-hospital mortality (H 5.3%, B 6.9%, T 8.9%, p<0.001). Conclusions: In this study, pancreatic cancer of the tail correlates with higher incidences of in-hospital complications and mortality. This suggest that the impact of biliary stents on outcome of hospitalized patients with PC may be limited. Anatomic location of pancreatic malignancy may also be utilized as prognostic factor in management of inpatient PC patients.