Transdermal drug delivery is a dosage form that is applied topically to the skin layer (epidermis) which helps to deliver the drug into the skin layer before entering the systemic circulation. Ethosomes are soft, and flexible vesicles which helps in rapid drug absorption. Ethosomes have better pharmaceutical properties than the conventional liposomes such as room temperature stability, and improved compatibility with the Stratum Corneum barrier. Ethosomes are non-toxic in nature and can be used in the preparation of cosmeceutical and it has better drug absorption to the skin. The most common disadvantage of ethosome is that it might not be cost-effective. The ethosomal patches might not stick to all skin types. The mechanism of ethosomes is mainly occurred due to increased lipid fluidity within the cell membrane caused by the ethanol in ethosome. As a result, skin permeability is increased. Ethosomes can be prepared by using cold method and hot method. Ethosome consists of various evaluation parameters which includes permeability studies, drug content studies, interaction study between the vesicle and filter membrane. Ethosomes can deliver various highly lipophilic drugs like minoxidil, testosome, CBD, and other antibiotic drugs. The most widely used application for ethosomal formulation is to transport the DNA topically into the skin layer for gene expression and hence ethosomes are used in the delivering the vaccines by transdermal route. Additionally, a study in this field allows for improved regulation of medication release in vivo and long-term safety analysis, providing effective treatment. Ethosomal preparations have promising future in delivering bioactive substances via transdermal distribution. The discovery of ethosomes and vesicle derivatives was a crucial breakthrough in vesicle research. Ethosomes are preferred because they are non-irritant to the GIT tract and avoid first-pass metabolism.

Diabetes is non-communicable disorder that is often a result of change in lifestyle or genetic variations among individuals across the globe. Diabetes  is a fatal condition and it is an unpredictable disorder hence it is regarded  as a tragedy, painful, horrible and terrifying disorder. This is why this article is intended to call out readers, researchers and scientists to do whatever could be done to prevent, withstand, overcome or cure diabetes particularly type 2 which is mostly found widely. Although the cure of diabetes has not yet been found, the goal is to be able to alter diabetic patient perceptive about the disorder so that they can bear the disorder as a part of who they are bravely, instead of being affected by the disorder condition, and to gradually alert patient awareness will improve patient disorder state, tolerance and acceptance while science and technology are advancing to find the cure or vaccine. Since this chronic disorder have no cure or vaccine, the patient suffers a lot from not only health problems but also psychological, emotional and financial problems therefore it is essential to develop strength within diabetic patients to withstand the disorder state via treatment, surgery, yoga, meditation, exercise, nutrition and habitual changes. Elevating diabetic mellitus patient’s attitude, knowledge, self-acceptance and strength will result into better patient compliance toward the treatment but also society’s perceptive will be enhanced by care toward diabetic mellitus patients, through various seminars and Counselling.