This briefpresents the lowest-current fully integrated sub-mm 3 OOK transmitter, the transmission of which is modulated by its supply voltage. By combining the transmitter with a glucose fuel cell that functions as both the power source and sensing transducer, a self-powered continuous glucose monitoring system (CGMS) contact lens can be emerged. The prototype in 55-nm deeply depleted channel CMOS with on-chip inductor and antenna requires an average current of 6.1 nA under 0.32-V supply without any external signal, which demonstrates the potential for self-powered operation.
A fully integrated CMOS circuit based on a vector network analyzer and a transmission-line-based detection window for circulating tumor cell (CTC) and exosome analysis is presented for the first time. We have introduced a fully integrated architecture, which eliminates the undesired parasitic components and enables high-sensitivity, to analyze extremely low-concentration CTC in blood. The detection window was designed on the high-sensitive coplanar waveguide line. To validate the operation of the proposed system, a test chip was fabricated using 65-nm CMOS technology. Measurements were performed after adding a tiny lump of silicone or a droplet of water on its detection window. The measured results show |S_21| degradation of −1.96 dB and −6.04 dB for the silicone and the droplet, respectively, at 1.4 GHz. In addition, in another measurement using magnetic beads, it is confirmed that the proposed circuit can analyze even low concentrations of 20 beads/µL.
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