AAE-C1-INH (acquired angioedema owing to C1-inhibitor (C1-INH) deficiency) is a dangerous illness that can lead to asphyxiation due to laryngeal edoema. Only around 1% to 2% of angioedema cases are classified as HAE or AAE, with HAE being 10 times more prevalent than AAE. The sole clinical distinction between HAE and AAE is the age at which symptoms appea, AAE-C1-INH is usually diagnosed after 40 years of age. There is no licensed therapy for AAE-C1-INH at this time. AAE-C1-INH attacks are treated with HAE-C1-INH medicines such plasma-derived C1-INH concentrate (pdC1-INH) and the bradykinin B2 receptor antagonist, icatibant. These on-demand medications are thought to be most helpful when provided early in the attack. However, there is a scarcity of published data on the efficacy and safety of AAE-C1-INH therapies.

Objectives: The systematic review was conducted to assess the relationship between varicoceles, risk of varicoceles or body mass index and obesity. Review Methods: The present systematic review scrutinized all the research articles published in English from 1971 to 12 July 2021 pertaining to the relationship between varicoceles, risk of varicoceles or body mass index and obesity. The systematic review was piloted under the PRISMA directives. Data Sources: Research articles were retrieved from the National Strength and Conditioning Association, Google Scholar, Web of Science, MEDLINE, Journal of Strength and Conditioning, and PubMed database using the vital search terms: risk of varicoceles or varicoceles in combination with obesity, body mass index. Results: There was a total of 370 studies found, with 29 publications included in this systematic review. There were 16 (55.1%) studies on the risk of varicoceles or varicoceles in combination with body mass index, 7 (24.1%) on the risk of varicoceles or varicoceles in combination with obesity, and 6 (20.7%) on the risk of varicoceles or varicoceles. Conclusions: Most cases in our systematic review included body mass index and risk of varicoceles or varicoceles, a few involved obesity and risk of varicoceles or varicoceles, while some included varicoceles relevant cases.