Acrokeratosis verruciformis of Hopf (AKV) is a rare cutaneous autosomal dominant genodermatosis described by Hopf in 1931. It usually presents at birth or may appear as late as 5 decade of life. It is characterized by multiple hyperkeratotic, verrucous papules/plaques to multiple planar wart like lesions on dorsal aspects of hand and feet. Due to rarity of the case, we present a case of AKV in a 60-year-old male that was diagnosed on histopathology. We the authors have attempted to describe the histological features of AKV with differential diagnosis of these lesions through review of literature.

Nevus lipomatosis cutaneous superficialis (NLCS) is a rare cutaneous hamartomatous lesion or connective tissue nevus having two clinical forms a). classical Hoffman-Zurhelle form and b). solitary form. We report a classical case of nevus lipomatosus superficialis in a 35-year-old male in the left flank. Histopathology showed presence of ectopic mature adipocytes extending to the papillary dermis with no connection to underlying subcutaneous fat, thus clinching our diagnosis. Excision is the ultimate cure with minimal chance of recurrence.

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Ovarian cystadenofibroma are rare slow growing benign epithelial ovarian neoplasms. It usually occurs as solid and cystic component. Most of the tumours are asymptomatic and detected incidentally during abdominal ultrasound for some other purpose. They may mimick malignant neoplasm with their gross appearance and imaging modalities. So a diagnosis of serous papillary cystadenofibroma of ovary on frozen section can save the patient from unwanted extensive surgery. We here in discuss a case of serous papillary cystadenofibroma of ovary in a 45 year old multipara that was diagnosed initially on frozen section and later confirmed on histopathology, thus highlighting the role of frozen section in diagnosis of intraoperative ovarian neoplasms.

Polycystic kidney disease is a rare developmental anomaly inherited as Autosomal dominant or recessive. Autosomal recessive polycystic kidney disease (ARPKD) is an intractable cystic renal disease that results in chronic renal failure. It has a profound effect on growing fetus and result in serious implications if pregnancy is continued in the long run after being detected on sonography. Although prenatal imaging studies and clinical findings are suggestive of ARPKD it can be accurately diagnosed by histopathology if an autopsy is performed in cases of infant death. In this article we here in present the features of ARPKD diagnosed antenatally by USG in a 22 yr female, and was confirmed further by fetal autopsy.