The role of CD8 T cells in anti-tuberculosis immunity in humans remains unknown, and studies of CD8 T cell–mediated protection against tuberculosis in mice have yielded controversial results. Unlike mice, humans and nonhuman primates share a number of important features of the immune system that relate directly to the specificity and functions of CD8 T cells, such as the expression of group 1 CD1 proteins that are capable of presenting Mycobacterium tuberculosis lipids antigens and the cytotoxic/bactericidal protein granulysin. Employing a more relevant nonhuman primate model of human tuberculosis, we examined the contribution of BCG- or M. tuberculosis-elicited CD8 T cells to vaccine-induced immunity against tuberculosis. CD8 depletion compromised BCG vaccine-induced immune control of M. tuberculosis replication in the vaccinated rhesus macaques. Depletion of CD8 T cells in BCG-vaccinated rhesus macaques led to a significant decrease in the vaccine-induced immunity against tuberculosis. Consistently, depletion of CD8 T cells in rhesus macaques that had been previously infected with M. tuberculosis and cured by antibiotic therapy also resulted in a loss of anti-tuberculosis immunity upon M. tuberculosis re-infection. The current study demonstrates a major role for CD8 T cells in anti-tuberculosis immunity, and supports the view that CD8 T cells should be included in strategies for development of new tuberculosis vaccines and immunotherapeutics.

delivers a low volumetric capacitance due to its insufficient active sites, as well as the existence of "dead volumes" without capacitance contribution. Especially, both the low conductivity and the poor ion transport ability of MnO 2 significantly hinder the charge transfer rate. [3] Therefore, it is highly desirable to improve the intrinsically electrical conductivity and ion diffusion ability aiming to achieve high performance of MnO 2 for supercapacitor applications.As known, electronic structure, as an important physical and chemical feature, significantly impacts the properties of metal oxide electrode materials. Consequently, optimized electronic structure of metal oxides has drawn dramatically attention in order to solve the problems of low electrical conductivity and poor ion diffusion ability. Specifically, the local coordination environment of metal atoms, including the oxidation state, the coordination number (CN), the coordination structure and so on, usually plays a significant role in electrical structure and charge diffusion dynamics of metal oxides. [4] Recently, several studies have been devoted to adjusting the coordination environment of metal atoms to regulate the performances of metal oxides based catalysis for oxygen evolution reaction, [4] hydrogen evolution reaction, [5] CO 2 reduction, [6] and organic oxidation. [7] However, the effect on the coordination environment of metal atoms on the capacitive performance of metal oxides, as far as we know, remains elusive. In particular, no effort has been made to tailoring electrochemical properties of MnO 2 as supercapacitor electrode material in considering adjusting the coordination environment of Mn atoms. Therefore, it is scientifically meaningful to optimize the coordination environment of Mn atoms, thus endowing MnO 2 electrode material with promising supercapacitor performances.Herein, MnO 2 -TEA nanosheets (NSs) were successfully prepared through a solution-based chemical deposition process using Triethanolamine (TEA) as a typical complex agent. Scanning transmission electron microscopy (STEM), X-ray photoelectron spectroscopy (XPS), and X-ray absorption spectroscopy (XAS) confirm that the coordination environment of Mn atoms in MnO 2 -TEA has been sufficiently adjusted by forming oxygen deficiency and more Mn-Mn2 (corner-shared Mn-Mn shell). As a result, the electrochemical performance of MnO 2 -TEA isThe electrochemical properties of transition metal oxides strongly depend on the coordination environment of metal atoms. Nevertheless, the relationship between the coordination environment of metal atoms and electrochemical performance of metal oxides is unclear, while the strategy of adjusting the coordination environment of metal atoms is rare. Herein, the engineering of the coordination environment of Mn atoms in manganese dioxides (MnO 2 ) by using a triethanolamine (TEA) complex-induced method is reported. The detailed experimental characterizations and density functional theory calculations show that the optimized Mn coordination e...

No abstract

No abstract