In this work bactericidal study of silver nanoparticles was taken up in combination with two standard antibiotics, ampicillin and gentamycin, for Salmonella typhi. The antibacterial activities of antibiotics were increased in the presence of AgNPs against test strains. The higher enhancing effect was observed for ampicillin in comparison to gentamicin against test strains. Silver nanoparticles were synthesized elctrolytically using silver wire of 99% purity as anode and carbon rod wrapped with LDPE as cathode. Silver nitrate [of Merck] of 0.01N is used as an electrolyte. Here tea extract is added as capping and mild reducing agent. The polyphenols theaflavins and thearubigins, present in tea perform the role of stabilizing or capping agents due to their bulky and steric nature. A brown coloured colloidal solution of silver nanoparticles is obtained. The as-synthesized silver nanoparticles were characterized using XRD, TEM and UV-Vis spectroscopy.

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In the present work, silver nanoparticles were synthesized using an easy, simple, and environment-friendly method based on principles of green chemistry in the absence of a sophisticated laboratory, and their anti-cancer properties were studied. Silver nanoparticles were synthesized using electrolytic deposition. As-synthesized nanoparticles were capped using black tea leaf extract. MTT assay was used to investigate anti-cancer activity. X-ray diffraction graphs show highly pure as-synthesized silver nanoparticles. Transmission electron microscopy images show well-dispersed spherical nanoparticles, with an average size of 9 and 15 nm, corresponding to different values of parameters used in the synthesis. For the MCF-7 cancer cell lines, 100% growth inhibition is obtained. The 50% growth inhibition concentration values against MCF-7 cancer cell lines were obtained at 70- and 30-fold dilutions of colloidal silver of almost the same concentration, 178 μg/ml, for both configurations. Silver nanoparticles can be synthesized, and their morphology can be tuned using the electrolytic deposition method with black tea leaf extract as capping agent. Silver nanoparticles with an average size of 9 nm are more effective those with an average size of 15 nm. The synthesis method is faster, cheaper, and environment friendly and renders a treatment option that can have high accessibility, reduced harmful side effects, and increased economic benefits.

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