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Aim:The aim of this study was to identify the prevalence of the primary non-odontogenic maxillofacial bone and cartilage tumors. Methodology:Clinical data and histopathological diagnoses of primary non-odontogenic maxillofacial bone and cartilage tumors, diagnosed between January 2010 and December 2019, were collected from the histopathological reports of Cairo governorate's educational hospitals and institutions.Results: Out of 11,444 archival reports -found in the maxillofacial bones and paranasal sinuses-collected from the mentioned study centers, 186 were reported as non-odontogenic maxillofacial bone and cartilage tumors, yielding a 1.63% prevalence. Osteosarcoma was the most common lesion, followed by chondrosarcoma and osteoma, respectively. Females were found to be more prone to the investigated tumors. Conclusion:The non-odontogenic maxillofacial bone and cartilage tumors represent 1.63% in Cairo governorate. Demographic variations were seen in some of the tumors studied, which differed from the literature; however, osteosarcoma was found to be the most prevalent lesion, accounting for over half of the lesions studied.