Derived from our original nomogram study by using the risk variables from multivariable analyses in the derivation cohort of 1383 patients with extranodal NK/T-cell lymphoma, nasal-type (ENKTCL) who were mostly treated with anthracyclinebased chemotherapy, we propose an easily used nomogram-revised risk index (NRI), validated it and compared with Ann Arbor staging, the International Prognostic Index (IPI), Korean Prognostic Index (KPI), and prognostic index of natural killer lymphoma (PINK) for overall survival (OS) prediction by examining calibration, discrimination, and decision curve analysis in a validation cohort of 1582 patients primarily treated with non-anthracycline-based chemotherapy. The calibration of the NRI showed satisfactory for predicting 3-and 5-year OS in the validation cohort. The Harrell's C-index and integrated Brier score (IBS) of the NRI for OS prediction demonstrated a better performance than that of the Ann Arbor staging system, IPI, KPI, and PINK. Decision curve analysis of the NRI also showed a superior outcome. The NRI is a promising tool for stratifying patients with ENKTCL into risk groups for designing clinical trials and for selecting appropriate individualized treatment.
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This study explores how to enhance H5 news user experience and promote news dissemination by constructing gamified creative design strategies. Through interviews and observations, eight key elements that affect H5 news user experience are summarized, and their weight values are calculated using AHP. Furthermore, the feasibility of gamification in H5 news is verified by comparing the high-weight elements with the eight core intrinsic motivators of gamification. A gamified design framework based on the Octalysisis proposed, and creative design strategies that aim to motivate the experience, set the incentive, and help to spread the news。
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