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Abbreviations: GABA, gama amino butyric acid; MAOI, mono amino oxidase inhibitor's; ODA, octa denoic acid; SSRI, selective serotonin reuptake inhibitors; TG, triglyceride AbstractTomato is an excellent fruit and can make people healthier reducing the risk of many diseases such as cardiovascular diseases, obesity, osteoporosis and cancer. The aim of the study is to evaluate the anxiolytic activity of tomato juice in animal model. Lycopene, present in tomatoes is thought to possess anxiolytic activity.Albino wistar mice were divided in three groups. Group I was considered as control group and given distill water. Group II was given low dose of tomato juice i.e. 10ml/ kg, group III received high dose of tomato juice i.e., 30ml/kg. All animals were given ad libitum diet and follow standard guidelines. The anxiolytic activity were evaluated with help of different models of anxiety such as head dip, open field, elevated plus maze and cage crossing apparatus. Our results showed positive anxiolytic effects. We concluded that tomato juice possesses positive anxiolytic effects due to presence of lycopene.