Since the beginning of the search of medicinally important synthetic compounds heterocyclic chemistry always remained the point of attraction because of their diverse biological properties. Compounds containing tetrazole moiety possess interesting biological activity. A series of tetrazole compounds were synthesized in order to obtain new compounds with potent antimicrobial, anti-inflammatory, anticancer, anticonvulsant, antibacterial activity etc. This review provides brief summary on the biological activities of various tetrazole derivatives that can helps in developing new tetrazole derivatives with better efficacy and more safety.