The data brought together in this report have been gathered from a wide territory and for a period extending over several years. The antimeningitis serum was first employed in 1906 and the latest figures relating to its use included in this report were furnished in 1912. There is no longer doubt that the serum has come to be applied under conditions fairly representing all known manifestations of epidemic meningitis. Hence the test of the serum treatment may be regarded as having been a rigorous one. The initial difficulties surrounding the administration by direct subdural injection have been largely overcome and doubtless will be still further mastered. Already the serum is being successfully applied in private as well as in hospital practice. This gain will probably be reflected in a still further diminution of the mortality since early injection plays such a large part in determining the results achieved. The 1,300 cases studied in this report are a part only of a far greater number of cases actually treated with the serum supplied by the Rockefeller Institute. It was not found possible to secure histories of all the cases treated; but there is no reason to suppose that the results of the analysis would have been essentially different if reports of a still larger number of cases had been returned. The decision arrived at is not based upon statistical computations alone, but upon objective data as well that are not readily misinterpreted. The conclusion that follows was first stated in 1909 as the result of an analysis of 400 serum-treated cases. It is supported by the study of the larger series of cases just presented. "In view of the various considerations presented, the conclusion may be drawn that the antimeningitis serum, when used by the subdural method of injection, in suitable doses and at proper intervals, is capable of reducing the period of illness; of preventing, in large measure, the chronic lesions and types of the infection; of bringing about complete restoration of health, in all but a very small number of the recovered, thus lessening the serious, deforming, and permanent consequences of meningitis; and of greatly diminishing the fatalities due to the disease."

C o m b i n e d a c t i o n o f v e n o m a n d r i c i n. R e l a t i o n o f a g g l u t i n a t i o n and

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lation with the continuous coaxing of the digestive tract, and the constant tempting of the palate to achieA-e the desired result. Not only for an esthetic effect, but also as a prophylactic and curatiA-e means, the logical fattening of individuals is of an importance which can hardly be overestimated.We know practically nothing about the ways in which proteins are held in living protoplasmic structures. The molecules of the protein compounds are relatively so large that as yet our physicochemical methods of measurement are inadequate to give us correct ideas of molecular size and intramolecular structure, although we know considerable about the lifeless and, in some re-1. Mead and Gies: Am.

The experimental study of poliomyelitis has yielded a large number of important facts relating to the spontaneous disease in man. The nature of the virus has been discovered, many of its properties have been ascertained, some of its immunity effects have been established, the clinical and pathological peculiarities of the disease have been elucidated, and a basis has been secured on which to develop measures of prevention.