When expressed in the absence of light chains, secretory Ig-micro chains (micro(s)) undergo endoplasmic reticulum associated degradation (ERAD). This process involves the recognition of terminally misfolded or unassembled molecules, their retro-translocation across the ER membrane and ubiquitination for degradation by cytosolic proteasomes. The molecular components of the ERAD pathway and their coordination remain largely unknown. Here we employed co-immunoprecipitation, silencing or over-expression assays to show that SEL1L and HRD1 are involved in the degradation of unassembled Ig-micro(s), but have minor effects on another substrate, TCR-alpha. SEL1L and HRD1 localize in the early secretory apparatus and are induced by ER stress and during B cell differentiation, concomitantly with the onset of massive IgM secretion. These findings reveal a role for SEL1L and HRD1 in IgM quality control.

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Amos, C.L.; Martino, S.; Sutherland, T.F., and Al Rashidi, T., 2015. Sea surface temperature trends in the coastal zone of British Columbia, Canada. Journal of Coastal Research, 31(2), 434-446. Coconut Creek (Florida), ISSN 0749-0208.Coastal sea surface temperature (SST), measured daily at the British Columbia (BC) Lighthouse network of stations, has been analyzed in this paper. A network of 14 of the 27 stations had (near) continuous data sets. These stations were clustered previously into exposed (northern/outer) and sheltered (southern/inner) sites. SST trends, evaluated between 1973 and 2010, show that the temperature contrast between these clusters is becoming greater: The northern/exposed stations are strongly influenced by interdecadal (Pacific Decadal oscillation [PDO]) and multidecadal oscillations in the north Pacific that are coherent with HadISST1.