We retrospectively studied 90 patients with postinfarction seizures to determine the clinical features (onset, number, type), prognosis, and electroencephalographic and computed tomographic findings; we included infarctions of all etiologies. Thirty-three percent of the 90 seizures appeared early (within 2 weeks after the infarction), and 90% of the 30 early seizures appeared within 24 hours after the infarction. Seventy-three percent of the 90 seizures occurred within the first year, and only 2% occurred >2 years after the infarction. Fifty-six percent of the 90 seizures were single, and status epilepticus was seen in only 8%. Early-onset seizures were more likely to be partial (57% of 30); late-onset seizures were more likely to be generalized (65% of 60). Thirty-nine percent of the 90 initial seizures recurred, and there was no significant difference in recurrence rate between early-or late-onset initial seizures. Twenty-two percent of the 90 initial seizures became multiple recurrent seizures, and we could identify a precipitating factor in 86% of the 35 recurrent seizures. The most common electroencephalographic abnormality in the 61 patients so examined was focal slowing (61%), but recurrent seizures occurred in 100% of the four patients with periodic lateralized epileptiform discharges and in 75% of the eight patients with diffuse slowing. Computed tomography in 61 patients showed that large infarctions were associated with early (p<0.021) and multiple (/><0.05) seizures. Deep infarctions on computed tomograms (cortical infarctions extending to subcortical structures) tended to cause recurrent seizures (/><0.057). Seizures in 88% of the 90 patients could be managed with monotherapy.

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Silent cerebral infarction is frequently seen in asymptomatic patients with atrial fibrillation. Age, history of hypertension, active angina, and elevated mean systolic blood pressure were associated with silent infarction at entry. The sample size was too small to determine whether warfarin had an effect on the incidence of silent infarction during the trial. Active angina at baseline was the only significant independent predictor for the later development of symptomatic stroke.

Using a double-blind, placebo-controlled, crossover design, we studied the effect of bromocriptine (15 mg daily) in 20 men with chronic nonfluent aphasia. The study was conducted over a 28-week period in two phases. In phase I, the patients received either bromocriptine or placebo; in phase II the treatments were crossed over. We evaluated each patient's language and nonverbal cognitive skills at the beginning and end of each phase and 6 weeks after completion of phase II. When compared with placebo treatment, bromocriptine did not significantly improve the patient's speech fluency, language content, overall degree of aphasia severity, or nonverbal cognitive abilities. Based on these results, bromocriptine is not recommended as monotherapy for the treatment of chronic nonfluent aphasia.

The COVID-19 pandemic hit mankind at an unprecedented scale. In their attempt to continue functioning, organizations asked employees to work from home. Though employees experienced stress due to ‘forced’ work from home and blurring of work–family boundaries, they had to cope with the challenging times. The present study aimed to unearth the aspects of boundary management and adaptation in the context of work from home during the COVID-19 pandemic. Thus, we address the research question ‘how did the employees adapt to the sudden forced work from home during the COVID-19 pandemic?’ Since work from home was forced upon employees during the pandemic leading to the violation of boundaries, we invoked the boundary theory that highlights the boundaries that people draw between their personal and professional lives to maintain a balance. Further, we referred to the theory of cognitive adaptation to explain how employees adapted to the challenges while working from home during COVID-19. We conducted in-depth interviews of 30 experienced professionals working in the technology-enabled sectors in India. We applied Gioia’s methodology to analyse the qualitative data. Four aggregate dimensions emerged from the data analysis, as employees involuntarily worked from home: stress due to work disruptions, threats to employee well-being, boundary violation and employee resilience. Our findings contribute to the current theoretical understanding of employee stress, boundary management, adaptation or resilience and employee well-being, in the context of forced work from home. While employees were stressed and boundaries had blurred between work and family, they adapted and demonstrated resilience to the unprecedented changes in their lives. Practical implications of our study include managers’ conscious efforts towards respecting work–family boundaries, enhancing employee well-being and building a resilience-promoting work environment.