The emergence of antibiotic resistance among pathogenic microorganisms is a major issue for global public health, as it results in acute or chronic infections, debilitating diseases, and mortality. Of particular concern is the rapid and common spread of carbapenem resistance in healthcare settings. Carbapenems are a class of critical antibiotics reserved for treatment against multidrug-resistant microorganisms, and resistance to this antibiotic may result in limited treatment against infections. In addition to in clinical facilities, carbapenem resistance has also been identified in aquatic niches, including marine environments. Various carbapenem-resistant genes (CRGs) have been detected in different marine settings, with the majority of the genes incorporated in mobile genetic elements, i.e., transposons or plasmids, which may contribute to efficient genetic transfer. This review highlights the potential of the marine environment as a reservoir for carbapenem resistance and provides a general overview of CRG transmission among marine microbes.

The role of RhoG in T cell development is redundant with other Racs subfamily members, and this redundancy may be attributed to redundant signal transduction pathways. However, the absence of RhoG increases TCR signalling and proliferation, implying that RhoG activity is critical during late T cell activation following antigen–receptor interaction. Moreover, RhoG is required to halt signal transduction and prevent hyper-activated T cells. Despite increase in TCR signalling, cell proliferation is inhibited, implying that RhoG induces T cell anergy by promoting the activities of transcription factors, including nuclear factor of activated T cell (NFAT)/AP-1. The role of NFAT plays in T cell anergy is inducing the transcription of anergy-associated genes, such as IL-2, IL-5, and IFN-γ. Although information about RhoG in T cell-related diseases is limited, mutant forms of RhoG, Ala151Ser and Glu171Lys have been observed in thymoma and hemophagocytic lymphohistiocytosis (HLH), respectively. Current information only focuses on these two diseases, and thus the role of RhoG in normal and pathological circumstances should be further investigated. This approach is necessary because RhoG and its associated proteins represent prospective targets for attack particularly in the therapy of cancer and immune-mediated illnesses.

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Breadfruit is recognized as a plant with the potential to be cultivated as an alternative staple food due to its high starch content and envisioned as a solution to mitigate hunger. The plant bears abundant fruits throughout the year with its productivity is comparable to other staple crops and it thrives well in countries where the poor population is high. Breadfruit however, exudes copious amount of latex upon harvesting and the stained epicarp often perceived as low in quality. Standardized methods of harvesting in plantations include a stage of latex draining by inverting the fruit for several hours. The latex will be drained to the ground and considered as an agricultural waste with no current commercial application. Despite being considered as a nuisance, plant latexes is a rich source of proteases functioned as a defensive mechanism against pathogenic attacks. In the effort to identify its potential, the breadfruit latex protease was purified and its characteristics were determined. The stability of the protease was investigated and its kinetics of inactivation was estimated in this research. Based on the analyses, breadfruit latex was discovered to consist of a serine protease with highly stable properties, potentially developed as an alternative commercial protease.

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