Pueraria mirifica (PM) extract contains phytoestrogen daidzein and genistein. In this study, we investigated the protective effect of PM extract, daidzein and genistein on a testosterone-induced prostatic hyperplasia in rats. Testosterone was administered at 3 mg kg(-1) to rats followed by the PM extract, daidzein and genistein for a period of 30 days with finasteride as positive control. The testosterone level was increased, indicating inhibition of 5α-reductase converting testosterone to dihydrotestosterone. This was confirmed by prostate-specific antigen level that significantly decreased when treated with PM extract, daidzein and genistein. The PM extract, daidzein and genistein reduced the increase in the prostate/body weight ratio in testosterone-induced rats. This gives indication that PM extract, daidzein and genistein possessed protective activity for the treatment of benign prostatic hyperplasia. The analysis of histoarchitechture of the prostate has also shown that there was a significant improvement in prostatic cells of the testosterone-induced rats when treated with PM extract, daidzein and genistein.

No abstract

During the third week of human pregnancy, an embryo transforms from two germinal disc layers of hypoblast and epiblast to three germinal layers of endoderm, mesoderm and ectoderm. Gastrulation is a complex process that includes cellular mobility, morphogenesis and cell signalling, as well as chemical morphogenic gradients, transcription factors and differential gene expression. During gastrulation, many signalling channels coordinate individual cell actions in precise time and location. These channels control cell proliferation, shape, fate and migration to the correct sites. Subsequently, the anteroposterior (AP), dorsoventral (DV) and left-right (LR) body axes are formed before and during gastrulation via these signalling regulation signals. Hence, the anomalies in gastrulation caused by insults to certain molecular pathways manifest as a wide range of body axes-related disorders. This article outlines the formation of body axes during gastrulation and the anomalies as well as the clinical implications.

Introduction: The scientific understanding gained from pharmacology investigations is used to support a wide range of medical therapies. As a result, pharmacology is essential in medicine. As a result of the coronavirus epidemic, several colleges throughout the world have resorted to online pharmacology learning, which has an indirect impact on student academic progress. Aside from learning styles, a student’s time management abilities are another essential aspect that affects their academic success. Methods: This is a cross-sectional study that employed a questionnaire to assess first-year medical students from Universiti Putra Malaysia’s Faculty of Medicine and Health Sciences’ learning style and time management skills. A series of pharmacological questions involving short answer questions was also given to the students to assess their pharmacology performance. Results: There was a significant weak negative correlation between superficial learning style and pharmacology performance (r=-0.272, p<.05). There was also a significant weak correlation between deep learning style and long range planning (r=0.256, p<.05) and including short range planning (r=0.263, p<0.5). Lastly, significant weak negative correlation on pharmacology performance and long range planning was seen (r=0.256, p<.05). However, there was no significant correlation between time management and pharmacology performance. Conclusion: Students that use a superficial learning style struggle in school, yet deep learning styles in both short and long term planning do not always increase pharmacology performance. A good time management skills does not guarantee a good pharmacology performance either. Other relevant factors, like as socio-demographic characteristics, that may contribute to this outcome, particularly during this epidemic, should be investigated further.