Background: Female coronary heart disease morbidity rate accelerate after the age of 45years. Altered serum lipid profile seen in menopause is one of the major determinants for developing cardiovascular diseases. Changes in lipid level in relation to the duration of menopause is to be investigated to prevent the emerging cardiovascular diseases. Aim and objective: To study the effect of duration of menopause on serum lipid profile in postmenopausal women. Methods: After getting ethical committee approval, in this cross sectional study, postmenopausal women attending Government Rajaji Hospital for master health checkup were selected. Women with duration of menopause less than 10years (n=30) were taken as group-I and more than 10years (n=30) were taken as group-II and estimation of serum lipid profile was done for all of them. Results: Statistical analysis was done by student's t test and the results were compared between group-I and group-II. In group-II, the mean values of total cholesterol (p=0.006) and low density lipoprotein levels (p<0.001) were increased significantly. However there was a significant decrease in high density lipoprotein level (p< 0.001). Conclusion:The elevated low density lipoprotein and the reduction of high density lipoprotein level increases the risk of developing cardiovascular diseases. So specific health education strategies are needed in postmenopausal women of longer duration.

Background: Menopause is a physiological change due to which women passes from fertile to infertile period. Decreased oestrogen production in post menopausal women alter the lipid metabolism. Since altered serum lipid profile seen in menopause is one of the significant risk factors for developing coronary heart diseases, influence of menopause on lipid levels is aimed to study. Aim and Objective: To study the influence of menopause on serum lipid profile by estimating the level of serum cholesterol and various lipoproteins in premenopausal and post menopausal women. Methods: After getting ethical committee approval, in this cross sectional study, women of age 45- 55 and normal BMI attending Government Sivagangai Medical College for master health checkup were selected. Informed consent obtained and estimation of serum lipid profile was done for all of them. Results: Statistical analysis was done by students t test and the results were compared between pre and post menopausal women. In post menopausal women, the mean values of triglycerides (p=0.016) and very low density lipoprotein levels (p=0.046) were increased significantly. Conclusion: Significant increase in serum triglycerides and very low density lipoproteins is due to menopause which causes changes in body metabolism. Serum lipid levels should be checked periodically after menopause and life style modifications should be adviced at an earlier stage.

Background: Hypertension is a major risk factor to the development of atherothrombosis which is of major health concern today. Neutrophils and platelets play a significant role in the development of atherothrombosis leading to cardiovascular events. Presently, neutrophil lymphocyte ratio and platelet lymphocyte ratio which can be easily calculated from complete blood count have been identified as novel systemic inflammation based indices predictive of cardiovascular risk. This study attempted to assess the relationship between neutrophil lymphocyte ratio and platelet lymphocyte ratio with hypertension.Methods: This cross-sectional study was conducted in 30 hypertensive patients with less than 2 years of duration and in 30 normal healthy adults between ages 40 to 60 years. Anthropometric measurements (height, weight) and blood pressure were measured. Complete blood count was also analyzed. Pearson’s correlation factor (r) was used to analyse quantitative data.Results: Both neutrophil lymphocyte ratio and platelet lymphocyte ratio showed a significant positive correlation with systolic BP observed by Pearson’s correlation. NLR (r=0.847, p<0.001) and PLR (r=0.209, p<0.009).Conclusions: Neutrophil lymphocyte ratio (NLR) and platelet lymphocyte ratio (PLR) can be used as reliable parameters in clinical practice and in epidemiological studies as indices of inflammation among hypertensives.