No abstract

Functionalized vinylaziridines, readily available from water-stable aziridine aldehydes have led to the construction of a variety of stereochemically rich heterobicycles. A cascade ring-opening/ring-contraction mechanism operates in the course of the process. These results underscore the notion that interesting and useful nitrogen-mediated relay processes can arise when elements of strain are merged with the manifolds of enamine/iminium ion reactivity.

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O2 can do: Innocuous molecular oxygen O2 is the only reagent needed to perform highly chemoselective biocatalytic single‐step alkene‐cleavage reactions (see scheme). The products are analogous to those of (reductive) ozonization and related metal‐based methods. In contrast neither special equipment nor an additional reducing agent is required. The biocatalytic reaction can be performed at ambient temperature. Depending on the substrate, aldehydes or ketones are obtained.

No abstract