Muscles are the only tissue in the body that has the ability to contract and therefore move the other parts of the body. Physical activity is the one important factor which affects the skeletal muscle function. Regular physical activity is recommended in youth today to improve the physical and mental well being. The aim of this study is to assess the skeletal muscle function in sedentary and physically active young adults by using Mosso's ergogaph and 40mm endurance test. A cross sectional study was conducted among 50 sedentary and 50 physically active healthy medical and paramedical students in the

Background: Muscles are the only tissue in the body that has the unique ability to contract which helps in movement of other body parts. Physical activity is one of the important factors which affect the skeletal muscle function. In the current scenario, regular physical activity is recommended to improve the physical and mental well-being in younger age groups. Aims and Objectives: The aim of this study was to assess the gender differences in muscle functions using hand-grip dynamometer, Mosso's ergograph, bicycle ergometer, and respiratory endurance in young adults. Materials and Methods: Anthropometric measurements such as chest circumference and chest expansion were taken and function tests were done to all the study participants. Muscle function was assessed using hand-grip dynamometer, Mosso's ergograph, and bicycle ergometer. Results: Maximum voluntary contraction, work done using Mosso's ergography and bicycle ergometer test, was higher in males when compared to females which is statistically significant (P < 0.05). Conclusion: From our results, we conclude that higher muscle strength was seen among males in both extremities compared to females. This could be mainly due to genetic factors and hormonal differences between both sexes. Higher muscle function could be achieved by training of the muscles. Hence, encouragement should be done to increase the physical activity in females in the modern world to lead a quality life.