Single nucleotide polymorphisms in the BTLN2 gene have been recently associated with the risk for sarcoidosis. We now aimed to study additional genetic alterations in BTLN2 as putative genetic risk. The CNV_ID 507, which was highlighted for its possible involvement in sarcoidosis because of its partly deletion of the BTNL2 gene, was tested for association in a cohort of 89 sarcoidosis patients and 89 matched controls, but our results indicated that CNV_ID 507 does not affect the genomic structure of BTLN2 as previously described. Additionally, we identified a heterozygous 1 bp deletion in exon 3, c.450delC. We genotyped 210 patients and 201 controls for c.450delC and observed similar genotype frequencies in both groups without a significant difference (P = 0.4996).

The word Psoriasis is derived from the Greek word 'Psora' for 'Itch'. The prevalence is approximately 1-3% in population. It usually appears first between ages of 15 to 30 years. The clinical course of Psoriasis is very variable. It is a very common, non specific skin disorder with distinct clinical feature and can be compared with 'Mandal Kushtha'. Mandal Kushtha is Kapha type of disorder, having signs like unctous, white, stable patches over skin. In a present study a clinical trial was conducted on 30 patients in order to prove efficacy of drug 'Panchatikta ghrita guggul' in Mandal Kushtha. Type of Study was plain randomized. 'Panchatikta ghrita guggul' was given in the dose of 1gm BD, with anupan of hot water, after meal for 90 days. After completion of treatment we found that, the total % of relief was 58% in subjective parameters.

The genetic disorders are the prime obstacles in the development of human being. The causative factors for these disorders are the improper formation of genotype. There are many causative factors for the derangement of genotype. Ayurvedic literature also stated about the genetic disorders as beejdosha vikara, & also there is elaboration about clearance of beej dosha. Hence in present paper the topic has been discussed.

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