A503areas covered with MEA, there are a high proportion of patients not covered by treatment due to actual pitfalls of contracting legislation. ConClusions: In Romania after 2014, the access via managed entry agreements represents the only solution for new innovative drugs not dominant versus present therapies. The types of MEA are limited and the actual MEA contracting process has several problems like disincentivizing the targeted therapies, long delays in negotiation and reimbursement and volatile price during MEA implementation. Meanwhile, both Payer and MAHs agreed that the legislation is not satisfactory and has to be revised.
Conclusion The study suggests the association of hMR in sexual transmission of HIV. Presence of hMR in lower number of vaginal epithelial cells of Serodiscordant females prevented binding and HIV entry into these cells.
A837was tolerability related to the number of withdrawals patients in each study, due to the presence of adverse events or treatment failure. The analyses were performed using software Addis (v.1.16.5) and RevMan (5.1). Results: A total of 979 documents were initially identified and 11 of them met the selection criteria to meta-analysis. No significant differences were observed between the number of withdrawals patients due adverse events in any meta-analysis of control versus intervention. The odds ratio ranged from 0.68 (CI 032-1.45) to placebo versus asenapine, 1.37 (CI 0.29-1.33) to placebo versus iloperidone and 0,71 (CI 0,36-1,41) to placebo versus lurasidone. However, all drugs were superior to their respective controls for the outcome of number of withdrawals by treatment failure, with odds ratio between 1.70 (CI 1.21-2.39) and 2.36 (CI 1.36-4.07). These results suggest that there is a higher effectiveness among patients for the treatment intervention that should be evaluated through clinical responses. Heterogeneity between studies (evaluated by I2 values) were low or moderate, not superior than 39,5% in any meta-analysis. ConClusions: Information and knowledge reunion and confrontation on the tolerability profile of a particular drug allows safer decisions over the therapeutic approach, focused on patient's interest which directly reflects on treatment follow-through and therapy effectiveness. In this study, we report evidence on asenapine, iloperidone and lurasidone greater tolerability profile compared to placebo in schizophrenia treatment.
A911contrária, mas o juiz deferiu a liberação do medicamento. ConClusions: Apesar da Recomendação N° 31 de 2009 e a Resolução N° 238 de 2016, do Conselho Nacional de Justiça, a proporção de conformidade entre as decisões judiciais e as NT/RTR encontrada no presente trabalho foi baixa. O estudo também encontrou menor influência das NT em comparação as RTR nas decisões judiciais.
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