The biologically active factors known as adipocytokines are secreted primarily by adipose tissues and can act as modulators of angiogenesis. Visfatin, an adipocytokine that has recently been reported to have angiogenic properties, is upregulated in diabetes, cancer, and inflammatory diseases. Because maintenance of an angiogenic balance is critically important in the management of these diseases, understanding the molecular mechanism by which visfatin promotes angiogenesis is very important. In this report, we describe our findings demonstrating that visfatin stimulates the mammalian target of the rapamycin (mTOR) pathway, which plays important roles in angiogenesis. Visfatin induced the expression of hypoxia-inducible factor 1α (HIF1α) and vascular endothelial growth factor (VEGF) in human endothelial cells. Inhibition of the mTOR pathway by rapamycin eliminated the angiogenic and proliferative effects of visfatin. The visfatin-induced increase in VEGF expression was also eliminated by RNA interference-mediated knockdown of the 70-kDa ribosomal protein S6 kinase (p70S6K), a downstream target of mTOR. Visfatin inactivated glycogen synthase kinase 3β (GSK3β) by phosphorylating it at Ser-9, leading to the nuclear translocation of β-catenin. Both rapamycin co-treatment and p70S6K knockdown inhibited visfatin-induced GSK3β phosphorylation at Ser-9 and nuclear translocation of β-catenin. Taken together, these results indicate that mTOR signaling is involved in visfatin-induced angiogenesis, and that this signaling leads to visfatin-induced VEGF expression and nuclear translocation of β-catenin. This article is part of a Special Issue entitled: 11th European Symposium on Calcium.

No abstract

Objectives: This study is the descriptive survey study to research the factors affecting successful aging of the elderly women in rural areas. Methods: The data was collected by using the tools of successful aging, health promoting behavior, depression based on 280 women aged over 65 in 16 centers for senior citizens located in B-district, J-province from June to July 2016, and 273 copies suitable for the study were analyzed. Results: It was analyzed that the successful aging and health promoting behavior showed the significant positive correlation (r = 0.86, p < 0.01), the successful aging and depression (r =-0.74, p < 0.01), and the health promoting behavior and depression (r =-0.67, p < 0.01) showed the significant negative correlation. The factors affecting the successful aging of the elderly women in rural areas were the health promoting behavior (β = 0.24, p < 0.001) and depression (β =-0.20, p < 0.001), and the explanatory power of model was 82.2% (F = 314.27, p < 0.001). Conclusions: This study suggests a need for promoting the health promoting behavior and the structural movements in the local community to mediate the psychological risk factors as depression for the successful aging of the elderly women living in a rural area.

No abstract

No abstract