Background: Dyspareunia is one of the most common but neglected female health problems which has a significant negative impact on a woman's sexual function. The aim of the study was to evaluate the effectiveness of application of PLISSIT counseling model on sexuality among women with dyspareunia. Design: A quasi experimental design was used. Setting: This study was conducted in outpatient clinic of obstetrics & gynecological department at Benha University Hospital. Sample: A purposive sample of all admitted women for a period of 6 months (280) woman: 200 out of them without dyspareunia and 80 with dyspareunia completed the PILLIST model. Tools: three tools were used I): A structured Interviewing Questionnaire Sheet. II): Dyspareunia assessment tool. III): Female Sexual Function Index (FSFI). Results: showed that the mean age of studied women were (35.21±9.03)years. More than one quarter of them complains of dyspareunia. there were statistically significant differences of the FSFI mean score between pre and post application as regard to elements of FSFI including desire, arousal, orgasm, satisfaction and pain (P<0.001). Meanwhile, there were no statistically significant differences regarding lubrication (P>0.4). Conclusion: PLISSIT counseling model had significant effect in improving sexuality among women with dyspareunia. The study recommended that the PLISSIT model should be used in a tailored and patient-centered approach in conducting sexual assessment and management of female dyspareunia.