Background: Clinical measurement of quality of life (QoL) for assessing reproductive problems should be considered as a standard investigation at the initial and continuing medical consultations with infertile people. Objective: The purpose of this study was comprehensive testing the psychometric properties of the Iranian version of fertility quality of life (FertiQoL). Materials and Methods: This cross-sectional study was conducted on300 women referred to infertility clinic. After linguistic validation, a semi-structured interview was conducted to assess face validity. Consequently exploratory factor analysis was performed to indicate the scale constructs. Discriminate validity was assessed using the known groups comparison. Convergent validity was evaluated by assessing the correlation between similar content on the 12-Item Short Form Health Survey (SF12), Hospital Anxiety and Depression Scale and FertiQol. In addition, reliability analysis was carried out with internal consistency. Results: The reliability of the Iranian version of the FertiQoL was satisfactory in all dimensions (0.77-0.83). Six factors (emotional, mind/body, relational, social, environmental, and tolerability) were extracted from the results of exploratory factor analysis. Discrimination validity showed that FertiQoL can differentiate between female patients with differing duration of infertility and number of children. Moreover, the results of convergent validity showed a favorable correlation between the related dimensions of SF12 (0.43-0.68), Hospital Anxiety and Depression Scale (0.47-0.52) and FertiQoL. Conclusion: The Iranian version of FertiQoL is valid and reliable for assessing infertility problems and the effects of treatment on QoL of infertile patients referred for diagnosis and treatment at infertility clinic.

In this research, a novel nanocarrier is synthesized based on tragacanth as a natural polysaccharide. For this purpose, carboxymethyl tragacanth (CMT) is first synthesized from tragacanth and then it is functionalized with isocyanate (IS) groups. In another parallel synthesis, magnetite nanoparticles (MNPs) are prepared by the co-precipitation method and coated with SiO 2 to form MNPs coated SiO 2 (MNPs@SiO 2 ). Then MNPs@SiO 2 is reacted with CMT-IS to form Fe 3 O 4 @SiO 2 /CMT. In the second step, the MNPs@SiO 2 /CMT surface is aminated by reaction with 3-amino propyl triethoxy silane (APTES) and then it is reacted with folic acid (FA) as a targeting agent to form MNPs@SiO 2 /CMT/FA nanocarrier. The synthesized nanocarrier is characterized by FT-IR, SEM, EDX, TEM, XRD, VSM, TGA, and zeta potential analysis and then it is loaded with doxorubicin (DOX) as a typical anti-cancer drug. The in vitro drug release studies are carried out from the DOX-loaded nanocarrier. The pH sensitivity of the DOX-loaded nanocarrier is examined attwo different pHs. The effect of DOX-loaded nanocarrier is investigated on MCF7 human breast cancer cells and the rate of cancer cell death is determined by MTT assay and drug IC50. The changes in the morphology of the tumor cell nuclei are observed using fluorescence microscopy.

Background: Although physical activity (PA) is essential, it is difficult to motivate people to take part in PA, especially the ones with high blood pressure (hypertension). One of the most commonly applied theoretical frameworks to change health behaviours is the Trans-Theoretical Model (TTM). The aim of this study was to examine the effectiveness of tailored, interactive multimedia software based on TTM for the promotion of PA behaviours among Iranian adults. Methods: This interventional study selected 120 healthy individuals aged 30 years old–50 years old from health centres in Delijan, Iran using multi-stage sampling. The participants were in the pre-contemplation and contemplation stages of PA behaviour. For the intervention, an active multimedia training (active life) based on TTM, like six training sessions of approximately 30 min (once a week) plus aerobic exercise videos were designed and provided to the intervention group. Data was collected using a valid and reliable questionnaire before and 6 months after the intervention and analysed using statistical tests. Results: The mean age of the participants was 38.20 (SD = 7.11) years old. Six months after the intervention, 61.7% of the individuals in the intervention group and 3.3% in the control group progressed to the action stage, which was significant only in the intervention group (P < 0.001). There was a significant increase in PA in both groups, yet this increase was significantly higher in the intervention group (36.02 [SD = 31.22] to 146.16 [SD = 90.43]; P < 0.001) compared to the control group (33.41 [SD = 28.33] to 54.41 [SD = 44.02; P < 0.001). Conclusion: The results obtained indicated that the implementation of educational intervention using multimedia designed based on TTM could be used as one of the effective strategies to promote PA to prevent hypertension in adults.