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One of the most important goals in bioinformatics is the ability to predict tertiary structure of a protein from its amino acid sequence. In this paper, new feature groups based on the physical and physicochemical properties of amino acids (size of the amino acids' side chains, predicted secondary structure based on normalized frequency of β-Strands, Turns, and Reverse Turns) are proposed to tackle this task. The proposed features are extracted using a modified feature extraction method adapted from Dubchak et al. To study the effectiveness of the proposed features and the modified feature extraction method, AdaBoost.M1, Multi Layer Perceptron (MLP), and Support Vector Machine (SVM) that have been commonly and successfully applied to the protein folding problem are employed. Our experimental results show that the new feature groups altogether with the modified feature extraction method are capable of enhancing the protein fold prediction accuracy better than the previous works found in the literature.

Network intrusion detection research work that employed KDDCup 99 dataset often encounter challenges in creating classifiers that could handle unequal distributed attack categories. The accuracy of a classification model could be jeopardized if the distribution of attack categories in a training dataset is heavily imbalanced where the rare categories are less than 2% of the total population. In such cases, the model could not efficiently learn the characteristics of rare categories and this will result in poor detection rates. In this research, we introduce an efficient and effective approach in dealing with the unequal distribution of attack categories. Our approach relies on the training of cascaded classifiers using a dichotomized training dataset in each cascading stage. The training dataset is dichotomized based on the rare and non-rare attack categories. The empirical findings support our arguments that training cascaded classifiers using the dichotomized dataset provides higher detection rates on the rare categories as well as comparably higher detection rates for the non-rare attack categories as compared to the findings reported in other research works. The higher detection rates are due to the mitigation of the influence from the dominant categories if the rare attack categories are separated from the dataset.

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