No abstract

In this article, we discuss the recent developments in palladium (Pd)‐catalyzed C(sp 3 )H activation assisted by native directing groups. Although studies on preinstalled (exogenous) directing group‐aided Pd‐catalyzed C(sp 3 )H functionalization reactions are still emerging, research on Pd‐catalyzed C(sp 3 )H activation assisted by native directing groups is growing at a considerable pace. Native directing groups refer to inherent functional groups or moieties present in small organic molecules. Accordingly, this article presents developments involving the Pd‐catalyzed C(sp 3 )H functionalization of small organic molecules containing functional groups, such as carboxylic acid, amine, azaarene, ketone, and part of peptide moieties, which act as native directing groups.

In this paper, we report a synthetic protocol for the construction of biaryl motif-based or π-extended azobenzene and alkylated azobenzene derivatives via the Pd(II)-catalyzed bidentate directing group (DG)-aided C-H activation...

Azobenzene-based unnatural amino acid motifs were synthesized via Pd(II)-catalyzed diastereoselective C(sp3)–H arylation of amino acid carboxamides with iodoacetanilides and Mills azo coupling.