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Background: Rheumatic disease in children is a chronic systemic disease with unclear etiology and pathogenesis. A growing number of evidence shows that there is an important relationship between chronic systemic diseases and oral cavity. However, there is still a lack of research on children's rheumatic diseases and oral health in Eastern countries.Methods: This study is a multicenter cross-sectional study. The oral health status and habits of children with rheumatic diseases in China were analyzed by investigating the oral health status of children with rheumatic diseases newly diagnosed in four hospitals in Shanghai.Discussion: This study will fill the gap in oral health status and habits of children with rheumatic diseases in Eastern countries. To analyze the influencing factors of oral health of children with rheumatic diseases in Eastern countries. So as to better provide plans and guidance programs for oral health of children with rheumatic diseases in Eastern countries.

Background and Objective: Fanconi anemia (FA) patients have a reduced ability to form blood cells, accompanied by multiple congenital malformations, mental retardation, solid tumors, and other symptoms. However, the molecular mechanism that causes FA is unclear, and few studies have addressed the regulatory mechanism of immune infiltration in FA. Here, we aimed to identify differentially expressed genes (DEGs), pathways, and immune infiltration involved in FA using integrated bioinformatics analysis and molecular mechanisms. Methods: The GEO gene chip database was searched for FA low density bone marrow tissue, and the content and proportion of 22 types of immune cells in the FA group and the normal group were analyzed using CIBERSORT. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis of FA differentially expressed genes (DEGs) using R language and related package programs was also performed.Results: The expression levels of T cells regulatory (Tregs), M2 macrophages, T cells CD8, dendritic cells resting, and T cells CD4 naïve in FA were higher than in the normal group. Furthermore, the expression levels of naïve B cells, monocytes, and resting mast cells in FA were lower than in the normal group. GO analysis of FA differential genes showed that “neutrophil degranulation,” “neutrophil activation,” and “neutrophil activation involved in immune response,” were most frequently enriched among biological processes, with “specific granule,” “tertiary granule,” “tertiary granule lumen” among cellular components, and “carbohydrate binding” among molecular functions. For the KEGG analysis, “Asthma” was most often enriched.Conclusion: This study obtained useful data related to immune infiltration, DEGs, and gene pathways of FA, and provides new evidence for immunotherapy and clinical assessment of FA patients. These results are potentially a useful reference for subsequent related scientific research.