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: Unprincipled use of antibiotics has led to the antimicrobial resistance (AMR) against mostly available compounds and now become a major cause of concern for the scientific community. However, in the past decade, green synthesized silver nanoparticles (AgNPs) have received greater attention for the development of newer therapies as antimicrobials by virtue of their unique physico-chemical properties. Unlike traditional antibiotics, AgNPs exert their action by acting on multiple mechanisms which make them potential candidates against AMR. Green synthesis of AgNPs using various medicinal plants has demonstrated broader spectrum of action against several microbes in a number of attempts. The present paper provides an insight into the scientific studies that have elucidated the positive role of plant extracts/phytochemicals during green synthesis of AgNPs and their future perspectives. The studies conducted so far seem promising still, a few factors like, the precise mechanism of action of AgNPs, their synergistic interaction with biomolecules, and industrial scalability need to be explored further till effective drug development using green synthesized AgNPs in healthcare systems against AMR is established.

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The present study is based on optimized green synthesis of silver nanoparticles (AgNPs) using Manilkara zapota fruit extract, formulation of topical gels, and evaluation for their antimicrobial properties. The results reveal that a reaction temperature of 35 °C and a reaction time of 11 h are the optimum conditions to get spherical AgNPs with a particle size of 100.7 nm and a zeta potential of −26.7 mV. The synthesized AgNPs formulated as topical gels demonstrate a broad-spectrum antimicrobial activity against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Aspergillus niger in comparison to the 0.2% (mass fraction) silver nitrate marketed formulation. The AgNPs loaded gels seem promising and could lead to a useful alternative for treating pathogenic infections.