Industrial activity in the district of Taman, Sidoarjo which produces liquid waste into streams, which then leads to a decrease in water quality. Kali Pelayaran have an important role that is to support and meet the needs of the community life, among others as a raw material for Drinking Water Treatment Plant (WTP), MCK activities, agricultural water resources and water resources fishery. This study aimed to describe the quality of the physical, chemical, water and heavy metal concentrations of chromium (Cr) in Kali Pelayaran Sidoarjo according to the water quality standards that have been established, using descriptive quantitative research methods. The sample used in the study was taken from Kali Pelayaran water at station I, II, III with 3 repetitions. The data captured includes physical parameters including pH, temperature.

Ginger (Zingiber officinale) and meniran (Phyllanthus niruri L.) is a cultural heritage in Madura ethnic, Indonesia. Madurese herbs were traditionally boiled using pottery which is made from clay. Clay consists of Silica (SiO2), Aluminum silicate (Al2O3), Magnesium (MgO), Calcium (CaO),) Iron (Fe2O3) and Potassium (K2O). This component contributes to the efficacy of traditional Madurese herbal medicine by forming bioinorganic complex compounds. The present study aimed to characterize the bioinorganic complex compounds from Madurese herbal medicine and predict their pharmacokinetics activity. Madurese traditional herbal medicine composition was determined using Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS). Then, Fourier-Transform Infrared Spectroscopy (FITR), X-Ray Fluorescence (XRF), Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) analysis were used to determine the functional group, transition metal composition, morphology, and the crystal structure of bioinorganic complex compounds from Madurese traditional herbal medicine, respectively. The pharmacokinetic activity was predicted using ADMET software. The results showed that Fe and Mn bind to hydroxyl groups (-OH) in the 6-gingerol and shogaol compounds to form bioinorganic complex compounds. The morphological structure of Madurese herbal powder was porous slabs. The crystal structures of Madurese herbal powder were amorphous and uniform in size. The pharmacokinetic activity analysis showed that Madura traditional herbal has a high solubility in water and easily absorbed by the body. In conclusion, bioinorganic complex compounds of Madurese traditional herbal medicine can be considered as a therapeutic agent in further research.

Traditional medicine employs many ingredients that have been used for generations for treatment and are based on society's norms. These ingredients are referred to as jamu. The research aim was to determine the types and uses of medicinal plants, the active compound content, and the potential of traditional herbal medicine as a fever-lowering bio-computation. The traditional herbal formula was determined using a direct interview method combined with a purposive sampling technique in this study. We used the software for phytochemical screening and molecular docking. COX-2 was used to analyse proteins, and six ligands were used: Quercetin, Curcuminoid, Zingerone, Heyneanone, Zerumbone, and Sabinene. This study discovered 22 different types of medicinal plants in Bangselok village, East Java, Indonesia. The Zingiberaceae family is frequently used as an ingredient in herbal medicine. Ginger, Lempuyang, Bangle, Temu Mangga, Temu Putih, and Temu Giring contain flavonoid compounds. The docking results showed that Quercetin, Zingerone, Heyneanone, Zerumbone, and Sabinene ligands were attached to domain A by the control of natural COX-2 ligands, namely NAG and EDO, predicting that they could be used as an anti-inflammatory and the combination of active compounds recommended as herbal medicine.

Indicators are substances that can be used to show the properties of a substance through a special change in its color. The types of plants used in this study as natural indicators are found in the surrounding environment for example purple sweet potatoes (Ipomea Batatas L) and butterfly pea (Clitoria Ternatea L). This research was conducted in 5 stages: 1) cut the purple sweet potato and butterfly pea into small pieces and then mash until smooth: 2) pour 5 tablespoons of alcohol and then leave until it settles; 3) pour the extract on 3 test tubes to test acid, base, and control; 4) drip the test solution on 2 test tubes; 5) then do testing to identify discoloration in purple sweet potato extract and butterfly pea a large amount of anthocyanin content in butterfly pea (Clitoria Ternatea L) affects the results of acid and alkaline testing so that the test results on butterfly pea extract (Clitoria Ternatea L) show a clear change in color. The purpose of this study is to identify the effectiveness of purple sweet potato extract (Ipomea Batatas L) and butterfly pea (Clitoria Ternatea L) as natural indicators of acid-base so that it can be used as an alternative learning medium.

Floating Net is a simple alternative cultivation methods. The river there is a garden in the Krembangan District Sidarjoi which is used as a place of cultivation of  Floating net fish oreochromis mossambicus (Oreochromis mossambicus), on the other hand is where waste disposal by the local community and some industries . This research aims to know the accumulation of heavy metals chromium (Cr) in the flesh of fish oreochromis mossambicus (Oreochromis mossambicus) and find out the feasibility of fish consumption oreochromis mossambicus at floating net on the river Krembangan Sidoaarjo. This research are observatif by using Purposive Random Sampling techniques. test the content of heavy metal chromium (Cr) in the flesh of fish oreochromis mossambicus (Oreochromis mossambicus) method using AAS (Atomic Absorbtion Spectrofotometry). The data generated in the analysis in quantitative descriptive.  In this research show that the heavy metal content of chromium (Cr) in the flesh of fish oreochromis mossambicus highs station III of 0.52 mg/Kg; I station of 0.51 mg/Kg II station of 0.48 mg/Kg on a sampling sedangkang the morning, at night the highest value on the station III of 0.50 mg/Kg; I station of 0.46 mg/Kg and the II of 0.39 mg/Kg. Average deposits of heavy metal Cr on fish oreochromis mossambicus (o. mossambicus) is still under the raw quality of the already established by the Director-General of POM 1989 i.e. amounted to 2.5 mg/kg but fall into the category bioakumulasi medium, so that fish oreochromis mossambicus is still worthy of consumption, but need to watch out for, considering the Cr are toxic, carcinogenic, bioakumulatif and biomagnifikasi would potentially interfere with health.