This study investigated the interactive effects of self-compassion, selfesteem, and age on mental health. Numerous previous studies have found that self-compassion has a significant positive association with well-being but most of these studies were conducted with young adults represented by college students. This study extended the previous findings by comparing its distinctive functions in different age groups. A total of 1,813 adults whose age ranged from twenties to fifties (M = 39.28 years, SD = 11.27) completed a questionnaire measuring selfcompassion, self-esteem, subjective well-being, and depression. The results of hierarchical regression analysis indicated that the positive relationship between selfcompassion and subjective well-being was rendered stronger with older adults. In addition, self-compassion moderated the relationship between self-esteem and depression regardless of age. These results imply that self-compassion may be complimentary to self-esteem in improving mental health, especially for older adults.