Nonsteroidal anti-inflammatory drug choice did not affect major clinical outcomes in horses with SSI lesions but had some effects on signs of pain. This study provides no evidence to recommend one NSAID treatment above another based on survival or the incidence of ileus; however, evaluation of a larger number of cases is required.

SummaryVerminous myeloencephalitis is a rare, but predominately fatal, cause of neurological disease in horses. A 6-year-old mare was admitted to the Royal Veterinary College Equine Referral Hospital following acute onset of depression, central unilateral blindness and compromised vision in the opposite eye. Based on pronounced eosinophilic inflammation detected in the cerebrospinal fluid (CSF) and diagnostic imaging findings indicating a space-occupying lesion within the brain, a presumptive diagnosis of aberrant parasitic migration causing parasitic encephalitis was made. Treatment consisted of anti-inflammatories and high doses of an anthelmintic. The horse's condition improved, the neurological deficits and observed space-occupying lesion within the brain resolved completely and the mare returned to full work. To the authors' knowledge, this is the first report describing complete recovery from suspected aberrant parasite migration in the CNS and will hopefully encourage treatment of suspected cases in the future.

SummaryReasons for performing the study: Severe hypertriglyceridaemia in horses and ponies with endocrine disorders has been reported anecdotally but has not been documented in the literature. Objectives: To describe historical and clinicopathological findings as well as progression and outcome in horses and ponies with severe hypertriglyceridaemia (serum triglyceride concentration >5.65 mmol/l) secondary to an endocrine disorder that were otherwise apparently healthy. Methods: Cases from 6 participating institutions were identified and case details extracted from the medical records. Results: Case details of 3 horses and 4 ponies were available. Presenting complaints included weight loss despite good appetite in 4 animals, while in 3 hypertriglyceridaemia was identified incidentally. All animals were bright and alert and showed a normal or increased appetite. Serum triglyceride concentrations ranged from 10.5 to 60.3 mmol/l. Other abnormalities included hyperglycaemia in 6 animals, suspected insulin resistance and mild to severe increases in hepatic enzyme activities. In 2 animals, moderate hepatic lipidosis was confirmed histologically. Three horses and 3 ponies were diagnosed with pituitary pars intermedia dysfunction based on clinical signs and basal adrenocorticotropic hormone (ACTH) concentrations or dexamethasone suppression test results. In 5 of these, type 2 diabetes mellitus was also confirmed, while one pony suffered from type 2 diabetes mellitus without concurrent pituitary pars intermedia dysfunction. Laboratory abnormalities improved in 4 animals with treatment (pergolide and/or insulin), in one horse specific treatment was not attempted, and in 2 ponies treatment was impaired by the owner or only partly effective. In one of the latter cases, biochemical abnormalities persisted for 7 years without apparent ill effects. Conclusions and potential relevance: Horses and ponies may develop severe hypertriglyceridaemia secondary to endocrine disorders that are associated with insulin resistance. Hypertriglyceridaemia can resolve with treatment of the endocrinopathy. Although biochemical evidence of hepatic compromise was present, clinical abnormalities were not noted in these animals.

: A 15‐year‐old part‐bred Welsh pony mare with a body condition score of 4/5 passed her placenta within the normal range of six hours after foaling. She subsequently developed postpartum metritis that resulted in severe quadripedal laminitis. The laminitis eventually resulted in delayed dehiscence, necessitating dorsal hoof wall resection in all four hooves. Eight months later she is alive and has reared her foal successfully, although ongoing remedial farriery is required to manage the consequences of this condition.

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