Background: COVID-19 emerged at the end of 2019 and is still one of the most important health problems today. In cancer patients, COVID-19 disease is more severe and fatal. Increased immune system response in COVID-19 leads to increased disease severity and mortality. This study aimed to evaluate the prognostic factors and inflammatory indices in patients with COVID-19 and genitourinary cancer.Methods: This retrospective study included 40 patients diagnosed with genitourinary cancer treated for COVID-19 between April 2020 and July 2021. A total of 27 potential prognostic variables were examined for univariate and multivariate analyzes for survival.Results: A total of 27 variables were analyzed univariable. 3 out of 27 parameters were found to be statistically significant in the univariate analysis: mechanical ventilation requirement (p=0.05), serum fibrinogen level (p=0.046), receiving radiotherapy in the last 28 days (p=0.000). In the multivariate logistic regression analysis; mechanical ventilation requirement independent risk factors for severe COVID-19 in genitourinary cancer (P=0.042).Discussion: In conclusion, mechanical ventilator requirement may be an independent risk factor for prognosis in COVID-19 patients with genitourinary cancer. The increase in fibrinogen due to hypercoagulopathy may be a prognostic independent predictor of survival in patients with genitourinary cancer with COVID-19. Larger, prospective studies are needed.