Background: COVID-19 emerged at the end of 2019 and is still one of the most important health problems today. In cancer patients, COVID-19 disease is more severe and fatal. Increased immune system response in COVID-19 leads to increased disease severity and mortality. This study aimed to evaluate the prognostic factors and inflammatory indices in patients with COVID-19 and genitourinary cancer.Methods: This retrospective study included 40 patients diagnosed with genitourinary cancer treated for COVID-19 between April 2020 and July 2021. A total of 27 potential prognostic variables were examined for univariate and multivariate analyzes for survival.Results: A total of 27 variables were analyzed univariable. 3 out of 27 parameters were found to be statistically significant in the univariate analysis: mechanical ventilation requirement (p=0.05), serum fibrinogen level (p=0.046), receiving radiotherapy in the last 28 days (p=0.000). In the multivariate logistic regression analysis; mechanical ventilation requirement independent risk factors for severe COVID-19 in genitourinary cancer (P=0.042).Discussion: In conclusion, mechanical ventilator requirement may be an independent risk factor for prognosis in COVID-19 patients with genitourinary cancer. The increase in fibrinogen due to hypercoagulopathy may be a prognostic independent predictor of survival in patients with genitourinary cancer with COVID-19. Larger, prospective studies are needed.

Background Cancer patients have an increased risk of COVID-19 compared to the healthy population. Due to increased proinflammatory cytokine excess, unopposed excessive immune response, that is, systemic inflammatory response; is the most important reason that increases the risk of mortality. In this study, we aimed to examine the parameters and inflammatory indices affecting mortality in lung cancer patients with COVID-19. Methods This single-center retrospective study included 66 patients diagnosed with lung cancer and treated for COVID-19 between April 2020 and July 2021. Neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), prognostic index (PI), modified Glasgow prognostic score (mGPS), and COVID inflammatory score (OIS) were calculated for all patients. Twenty-seven potential prognostic variables were chosen for univariate and multivariate analyses. Results A total of 28 variables were analyzed univariable. Seven variables were identified to have prognostic significance: receiving chemotherapy in the last 28 days, hospitalization in the intensive care unit, mechanical ventilation requirement, COVID 19 corticosteroid treatment doses, hemoglobin, platelet count, uric acid. Multivariate analysis by Cox proportional hazard model, including seven prognostic significance factors evident in univariate analysis. In the multivariate logistic regression analysis; hemoglobin, uric acid were independent risk factors for severe COVID-19 in lung cancer. Conclusion Serum hemoglobin and uric acid level were identified as important prognostic factors in lung cancer patients with COVID-19. These findings may facilitate the prediction of survival in lung cancer patients with COVID-19. In the literature, there is no previous study on the effect of uric acid on prognosis in patients with COVID-19 and lung cancer. Prospective studies with larger patient populations are needed to confirm this study.

Background COVID-19 is one of the pandemics affecting the whole World. Breast cancer is the most common cancer in women. Therefore, the prevalence of COVID-19 increases in breast cancer pateients. In this study, it is aimed to examine the factors that may be effective on COVID-19 disease severity in breast cancer patients. Method This study was carried out as a single-center and retrospective study with a total of 65 patients with a pathological diagnosis of breast cancer who were hospitalized between April 2020 and June 2021, and PCR positive in COVID-19 nasopharyngeal swab sample. The patients were divided into two groups, mild and severe. 35 patients were in the mild groups and 30 patients were in the severe group. Patients with oxygen saturation below 93 percent, followed and treated in the intensive care unit, more than 50% lesion increase in chest imaging in the first 24–48 hours, needing non-invasive or invasive mechanical ventilation, acute respiratory distress syndrome, shock and multiple organ failure were included in the severe group. Results a total of 17 parameters that may affect disease severity were analyzed with univariate logistic regression analysis of the Kaplan- Meier test. As a result of the univariate analysis performed to evaluate the potential factors that may affect the severity of the disease, statistically significant differences were found: the patient had diabetes mellitus (P = 0.050), the neutrophil count increased during hospitalization (P = 0.002), the lymphocyte count decreased at admission (P). =0.001), high d-dimer level during hospitalization (P = 0.007), lymphocyte to monocyte ratio above 2.55 (P = 0.016). Discussion As a result, the presence of diabetes mellitus, neutrophilia, lymphocytopenia, high D-dimer, increased lymphocyte to monocyte ratio in patients with breast cancer may aggravate the course of COVID-19 disease. These parameters may be predictive for closer follow-up in terms of clinical deterioration of the patients. More recent studies are needed.