Cardiovascular diseases (CVDs) are a primary cause of death globally. A few classic and hybrid treatments exist to treat CVDs. However, they lack in both safety and effectiveness. Thus, innovative nanomaterials for disease diagnosis and treatment are urgently required. The tiny size of nanomaterials allows them to reach more areas of the heart and arteries, making them ideal for CVDs. Atherosclerosis causes arterial stenosis and reduced blood flow. The most common treatment is medication and surgery to stabilize the disease. Nanotechnologies are crucial in treating vascular disease. Nanomaterials may be able to deliver medications to lesion sites after being infused into the circulation. Newer point-of-care devices have also been considered together with nanomaterials. For example, this study will look at the use of nanomaterials in imaging, diagnosing, and treating CVDs.

Venoms from the deadliest animals, including spiders, scorpions, bees, and centipedes, are composed of a complex mixture of various peptides developed to catch prey and defend other animals. Venoms are composed of several bioactive molecules such as proteins and peptides that modify physiological conditions in other organisms. These bioactive peptides penetrate tissues and blood vessels to encounter numerous receptors and ion channels, and modulate their activities. Venoms are being employed to treat various medical issues, including cardiovascular diseases. Venom peptides regulate several ion channel behaviors, such as voltage-gated sodium (Nav), calcium (Cav) and potassium (Kv) channels, and are set as a therapeutic approach. In this perspective, we emphasized the isolated lethal venomous peptides' effects on cardiac ionic channels and their mechanisms of action for the cure. We also summarize the highlights and molecular details of their toxin-receptor interactions and prospects to develop peptide therapeutics for respective cardiac electrophysiological diseases.