Verrucous carcinoma (VC) is an uncommon variant of squamous cell carcinoma characterized by proliferative outgrowing clinical appearance of the tumor, Incidence of VC is 2-12 % among oral cancers, the true incidence of VC can be accessed only from surgically treated cases since thorough processing of the entire tumor is necessary for accurate diagnosis, foci of invasive squamous cell carcinoma are found often in the substance of these tumors, thus, over reporting of this tumor is not uncommon. The retrospective data of a tertiary cancer hospital was analysed to understand the clinical challenges and outcome of patients with VC. The frequent association of VC with second primary oral cancer (22.7 %) observed in our series highlights the multi centricity of carcinogenesis in these patients.

Introduction. Among all prognostic factors, “margin status” is the only factor under clinician's control. Current guidelines describe histopathologic margin of >5 mm as “clear margin” and 1–5 mm as “close margin.” Ambiguous description of positive margin in the published data resulted in comparison of microscopically “involved margin” and “close margin” together with “clear margin” in many publications. Authors attempted to compare the outcome of close and clear margins of stage I and stage II squamous cell carcinoma of oral cavity to investigate the efficacy of description of margin status. Patients and Methods. Historical cohorts of patients treated between January 2010 and December 2011 at tertiary cancer hospital were investigated and filtered for stage I and stage II primary squamous cell carcinomas of oral cavity. Patients with margin status of tumor at margin or within 1mm from cut margin were excluded and analyzed in multivariate logistic regression model for locoregional recurrences and Cox regression for overall survival. Results. A total of 104 patients fulfilled the abovementioned criteria, of whom 36 were “clear margin” and 68 were “close margin” with median period of follow-up of 39 months. There was no significant difference in locoregional recurrence (P value: 0.0.810) and survival (P value: 0.0.851) among “close margin” and “clear margin” patients.

a b s t r a c tMyxofibrosarcoma occurs frequently in the extremities of older individuals and is rarely reported in the head and neck sites. The present case is a rare clinical presentation with respect to site, size and origin of the tumour. Occurring at an intraoral site, the tumour was 8 cm × 7 cm × 5.5 cm in dimensions. Myxofibrosarcoma is known to originate from subcutaneous tissues in the majority of the cases. The origin of the tumour was ambiguous in the current case, as it appeared entirely intraorally.The tumour was resected with adequate margin and following which post-operative adjuvant radiotherapy was given.

HighlightsSalivary duct carcinoma is a rare aggressive tumor.Current case showed recurrence free 40 months follow up.HER2/neu negativity in this case might have significance regarding recurrence free survival.

BACKGROUND Locally Advanced Carcinoma Breast Breast cancer is one of the most common malignancies in female and in developing countries, majority of them present in locally advanced stages. Patients presenting with LABC constitute a diverse group for which a variety of treatment modalities have be en instituted with coordinated treatment planning among the medical oncologist, surgical oncologist and radiation oncologist. The study is conducted to know the incidence, age distribution and common modes of presentation. MATERIALS AND METHODS This is a prospective study of 50 patients presenting with Stage III and inflammatory breast cancer to MNR Medical College and Hospital, Department of General Surgery from December 2014 to December 2015. RESULTS Majority of the patients, 35 (70%) of the patients were doing well at the end of the study. The most distressing outcome was development of distant metastasis in 4 (8%) of the patients. These cases included one inflammatory carcinoma and other three were Stage IIIB, two of which had not responded to NACT and had remained inoperable. Local recurrence was seen in 3 (6%) of the patients. Two of these cases were of Stage IIIA and was not on radiotherapy. One case belonged to Stage IIIB and had completed radiotherapy; 8 (16%) of the cases were lost to followup. CONCLUSION Multimodality therapy is effective in treatment of locally advanced carcinoma of breast, but distant metastasis is seen in four patients and local recurrence in 3 patients shows that management is still a challenge and improvements in current therapies and newer modalities are needed to further reduce disease free and overall survival.