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BACKGROUNDCirrhosis of Liver is the common hepatological disorder in clinical practice. The development of Ascites is a marker of Prognosis. Spontaneous Bacterial Peritonitis is responsible for the deterioration of the condition. Without prompt diagnosis, the diagnosis and treatment of infected Ascites may be delayed, leading to death. Study was conducted in 50 patients of Govt. General Hospital, Anantapuramu, to determine the prevalence of spontaneous bacterial peritonitis in Cirrhosis of liver with Ascites patients. Of these 50 patients, 9 patients (18%) showed features of SBP, 7 patient's (77.7%) PMN count was >250/mm 3 , 2 patient's (22.3%) culture was positive for E. coli. All cases with abdominal pain, tenderness and altered sensorium were having features of SBP. Study showed SBP more common in advanced liver disease. Presence of Jaundice had no significance, but the degree of Jaundice is an indicator of SBP. Study shown Cirrhotic patients with constitution of symptoms should be screened for SBP and started on Antibiotic therapy so that mortality can be reduced.

BACKGROUNDIndia is the world's second largest country with HIV. The prevalence of HIV among Indian adults is 0.26%. In 2015, India had 2.1 million people living with HIV. HAART has reduced HIV mortality significantly. It is clear now that prolonged treatment that maintains suppression of plasma viraemia is unlikely to eradicate HIV. Therefore, therapy must be lifelong. Unfortunately, up to 25% of individuals discontinue HAART due to treatment failure, toxic effects or noncompliance.The aim of the study is to study prospectively various HAART drugs induced adverse reactions among HIV patients within 6 months of therapy. To evaluate the correlation between the adverse drug reactions with various demographic factors, clinical symptoms at the time of initiation of treatment, CD4 count at the baseline and various HAART regime.

Background: Diabetics are more prone for infections, as well infections can lead to various complications. The aim of the study is to isolate aerobic bacteria and its antibiotic sensitivity pattern among symptomatic and asymptomatic UTI Diabetic patients. Methods: Urine samples of both symptomatic and asymptomatic group of Diabetic patients were collected and sent to Department of Microbiology for culture and sensitivity analysis. All urine samples were assessed at aerobic culture lab using standard techniques, semi quantitative culture was done. Various Organisms were isolated and antibiotic sensitivity testing was done by Modified Kirby Bauer method using CLSI guidelines. Results: Organisms isolated among Symptomatic UTI diabetic patients were: Escherichia coli -24%, Klebsiella pneumoniae & Staphylococcus aureus -14%, CoNS & Proteus mirabilis -4%, Pseudomonas aeruginosa & Enterobacter aerogenes -6% and among asymptomatic UTI diabetic patients: Escherichia coli -10%, Klebsiella pneumoniae -8%, Staphylococcus aureus -6%, Pseudomonas aeruginosa & Enterobacter aerogenes -2%. Most of the isolates of both symptomatic and asymptomatic UTI shown more resistant to amoxyclav, cefotaxime and shown about 100% sensitive to gentamicin, nitrofurantoin, norfloxacin, ofloxacin. Conclusion: As Antibiotic Resistance towards various organisms are also reporting more and more now-a-days. Both symptomatic and asymptomatic UTI has to treat in a proper way and diagnosis by culture is must, as poly microbial organisms are usually detect.