BackgroundDLBS3233, a combined bioactive fraction of Cinnamomum burmanii and Lagerstroemia speciosa, has preclinically demonstrated its beneficial effects on glucose and lipid metabolism through the upregulation of insulin-signal transduction. This study evaluated the clinical efficacy of an add-on therapy with DLBS3233 in type-2 diabetes mellitus subjects inadequately controlled by metformin and other oral antidiabetes. MethodsThis was an open and prospective clinical study for 12 weeks of therapy, involving type-2 diabetes mellitus patients who had been treated with two oral antidiabetic agents for at least 3 months prior to screening, yet, with HbA1c level was still beyond 7.0 %. DLBS3233 was given orally at the dose of 100 mg once daily in addition to their baseline oral antidiabetes medication. The primary end point was the reduction of HbA1c level; and the secondary end points were changes of fasting and 1-h postprandial glucose, homeostatic model assessment-insulin resistance, adiponectin, and lipid profile, from their respective baseline. Results After 12 weeks of treatment, the HbA1c level was reduced by 0.65±1.58 % (p=0.001) from baseline (9.67±2.11 %); while the 1-h-PG level was reduced by -1.45±3.89 mmol/L (p=0.021) from baseline (15.29±4.49 mmol/L). Insulin sensitivity, lipid profile and adiponectin level were improved to a considerable extent. DLBS3233 did not adversely affect body weight, liver, and renal function. Most adverse events observed were tolerably mild and they all had been resolved by the end of the study. ConclusionsThe add-on oral antidiabetes therapy with DLBS3233 at the dose of 100 mg once daily helped type-2 diabetes mellitus patients to improve their glycemic control, enhance insulin sensitivity, lipid profile, and adiponectin level. In addition, DLBS3233 treatment concomitantly with other oral antidiabetic agents was proven safe and tolerable in type-2 diabetes subjects.

using Cockroft-Gault equation. Correlation between blood lipid profiles and renal function was statistically analyzed by Pearson test. Result: The samples included 137 T2DM patients (76 male subjects and 51 female subjects) with mean age (62±11.35) years old. Mean of eGFR was 76±27.03 mL/min/1.73 m 2 . The laboratory result of tot-Chol was 203±49.09 mg/dL, triglyceride was 186±163.56 mg/dL, LDL-Chol was 123±41.79 mg/dL, HDL-Chol was 47±13.55 mg/dL. There was no significant correlation between tot-Chol, triglyceride, LDL-Chol, HDL-Chol and renal function (p = 0.816; p = 0.869; p = 0.957 and p = 0.082, respectively). Conclusion:In our study, there was no correlation between lipid profiles and renal function in patients with T2DM.

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Background: Cross-sectional studies have reported risk factors and prevalence of type 2 diabetes. Incidence rates and risk factor for type 2 diabetes in Chinese populations are not well known. The aim of this study was to evaluate the impact of weight change and other risk factors on incident type 2 diabetes in Qingdao, China. Method: The population-based prospective cohort study was based on subjects aged 35-74 years who participated in Qingdao Diabetes Survey in 2006. The subjects were free of diabetes at baseline. A total of 1,294 subjects attended the follow up survey between 2009 and 2011. Diabetes diagnosis was classified according to the World Health Organization and International Diabetes Federation 2006 criteria. A logistic regression was built using the backward stepwise selection to assess effect of the risk factors on incident type 2 diabetes.Result: During a 4-year follow up, 120 cases of incident type 2 diabetes was identified, with cumulative incidence of diabetes of 11.8%. Participant who developed type 2 diabetes were significantly older, have significantly higher age-adjusted BMI, waist circumference, systolic blood pressure and total cholesterol than subjects who remained without diabetes both in urban and rural areas. Among individuals without diabetes at baseline, age, living in rural areas, baseline BMI and weight change contributed to the development of diabetes independently. The multivariate adjusted relative risk (95% CIs) for incidence of diabetes were 1.

Conclusion: Modified hypoglycemia score was negatively correlated with 1,5-AG in well-controlled type 2 diabetes patients, but more number of subjects would be required to estimate the 1,5-AG as an independent determinant. However, in the subgroup analysis with insulin group, we could identified both the score and 1,5-AG levels were strongly correlated with indices of mean glucose and glycemic variability, which were also closely related with the hypoglycemia observed during the CGMS.