Learning media based on three levels representation using Prezi is an alternative learning media that is more interesting and dynamic. Chemical equilibrium material that is difficult to understand by students will be overcome by using this learning media. This research is aimed to develop learning media based on three levels of representation using Prezi and to test the validity and practice of learning media developed. This research is a research development of Research and Development (R & D) by using 4-D development model consisting of 4 stages namely (1) define (definition stage), (2) design (design stage), (3) develop (development stage) and (4) disseminate (stage of dissemination). This study is limited to the development stage. The research instrument used in the form of a questionnaire in the form of validity sheet and practicality. From the results of validity test obtained the average value of kappa moment of 0.89 with the category of very high prevalence. Practicality test results on the students obtained the average value of kappa moment of 0.80 with high practicality category, while the teachers obtained by 0.92 with the category of very high practicality. Based on the result of the research, it can be concluded to produce learning media based on three levels of reprsentation using Prezi on chemical equilibrium material is valid and practical, so it can be used in the learning activity of chemistry class XI in SMA / MA.