High cholesterol diet leads to increase of plasma cholesterol and subsequently will end up with hypercholesterolemia. Ignorance of healthy food and lacks of activity are the trend of modern life style. These conditions exacerbated the incidence of hypercholesterolemia in either developed or developing countries. This research aims to determine potential of anredera cordifolia leafs extracts as an anti-hypercholesterolemia by lowering of malondialdehyde (MDA) and 8-hydroxy-diguanosine (8-OHdG) blood levels in hypercholesterolemia Wistar Rat. This is an experimental study applied post only control group design. A number of 15 male wistar rats were used in this study. Rats were randomly divided into 3 groups, i.e. negative control group (C1), positive control group (C2) and anredera cordifolia leaf extract at dose of 100 mg/kg BW group (T). MDA was determined based on malondialdehyde assay (NWLSSTM).  8-OHdG was determined based on oxidative DNA Damage (Cell Biolabs, Inc). The mean difference between control and treatment was assessed by applying ANOVA and consider significant at p < 0.05. In this study, we observed that there were a significant of MDA and 8-OHdG levels between group C1 and T; C2 and T within p < 0.05. This result indicates anredera cordifolia leafs extract has an ability to inhibit hypercholesterolemia in wistar rat fed with high cholesterol diet.

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Objective: Increased production of reactive oxygen species is one of the causes of hyperglycemia. This study aims to determine the effectiveness of Indonesian bay leaves (Syzygium polyanthum) extracts as an antidiabetic agent in decreasing blood glucose and advanced glycation end products (AGEs) level of alloxan-induced hyperglycemic Wistar rats.Methods: This research is a real experimental study with pre- and post-test control group design. The study begins with the induction of hyperglycemia in 40 Wistar rats using alloxan. Subsequently, hyperglycemic rats were divided into 6 groups, namely, the positive control group (P0); the treatment group by not giving the intake of Indonesian bay leaf (P1); the treatment group was given the extract of Indonesian bay leaves (S. polyanthum) 0.5 mg/kg body weight/day (P2); treatment group given Indonesian bay leaves extract 2.0 mg/kg body weight/day (P3); treatment group given Indonesian bay leaves 5.0 mg/kg body weight/day (P4), and P5 was treatment group with glibenclamide (hyperglycemia-lowering medication).Results: In the treatment of P1, P2, P3, P4, and P5 groups, it can be seen that there are decreases of blood glucose and AGEs level between pre- and post-test comparison. However, the most significant drop in mean plasma glucose level was observed at the dosage 5.0 mg kg-1 (P4).Conclusion: The administration of Indonesian bay leaf extracts at a dose of 5.0 mg/kg body weight/day have an antidiabetic effect through decreasing blood glucose and AGEs level in alloxan-induced hyperglycemic Wistar rats.

Background: This research aims to find a cure for anti-inflammation, based on the utilization of red piper crocatum. The research was started with descriptive study to explore active components of red piper crocatum leaf and followed by experimental study to investigate red piper crocatum activity of the leaf extract in anti-inflammation induced Wistar rat. In this research observed three dominant components: caryophyllene bicyclo [5.2.0] none, 2 methylene-4, 8,8-trimethyl-4-vinyl; phytol; 5,9-propano-5H-benzocycloheptene, 6,7,8,9-tetrahydro-7,11-bis(methylene); 4,4-ethynedioxy-2-hexadecen-15-15 olide 1,4,9-trioxaspiro [4,15] eic os-6-en-8-one, 10 methyl; 1H-1,2,4-triazole-5(H)-thione,4-allyl-3-(3-furyl); Benzofuran,2,3-dihydro-2-methyl-7-phenyl which are possibly active to inhibit anti-inflammation to atherosclerosis. Bad eating habits also can cause various health problems, such as obesity, dyslipidemia, inflammation to atherosclerosis. This study was conducted to investigate of red piper crocatum leaves extract as an anti-inflammation through decrease of biochemistry markers TNF-α and IL-6 levels. Method: This is a true experimental with randomized pre-test and post-test control group design, using 50 Wistar rats that are divided

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